Volume 6, Issue 2 (9-1999)                   RJMS 1999, 6(2): 107-115 | Back to browse issues page

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Borjian L, Fesharaki M. Ulcerogenic Effect of Prednisolone on Rat Gastric Mucosa and Role of Neutroohils. RJMS 1999; 6 (2) :107-115
URL: http://rjms.iums.ac.ir/article-1-1769-en.html
Abstract:   (13928 Views)

The ulcerogenic effect of corticosteroids has always been subject of controversial discussion. In this study, which is a part of another extensive study (the role of neutrophil in induction of gastric mucosal injury by different agents), the effect of prednisolone, as a widely used corticosteroid, on the rat gastric mucosa, was investigated. Prednisolone (1 mg/kg) induced acute mucosal injury (after 3 hours) in special regions of the rat stomach.

Moderate neutropenia, induced by methotrexate, significantly reduced the prednisolone induced injury.

Profound neutropenia induced by anti-neutrophil serum, completely prevented the induction of injury by prednisolone. A specific muccosal area of the rat stomach is quite similar to the mucosa of the esophagus. Neutropenia also diminished the ulcerogenic effect of prednisolone in this area. These findings suggest a role of neutrophil in induction of gastric, and probably eosophageal acute mucosal injury by prednisolone in rat.

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Type of Study: Research | Subject: Human Physiology

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