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Abstract:   (228113 Views)

Background & Aim:

stomach or intestine, leading to distension of the organs. Approximately 20% of people aged 65-93 have experienced

abdominal distension, often due to gaseous build-up. A wide range of approaches, including chemical drugs and dietary

modifications, are utilized to treat flatulence. One of the most common therapies for flatulence is dimethicone. On the other

hand, the use of alternative therapies, particularly herbal remedies, is also becoming increasingly common. The aim of this

study was to compare the effects of carmint as herbal therapy versus those of dimethicone on flatulence.

Flatulence is a condition which is defined as the presence of excessive amounts of air or gas in the

Patients and Method:

flatulence. After determining appropriate inclusion and exclusion criteria, the patients without any organic disorders were

selected and randomly divided into two groups: 42 patients under herbal therapy with carmint in group A and 40 patients

receiving dimethicone in group B. Both groups received the treatment for two weeks. Then the patients were followed up

with phone calls one and three weeks after the beginning of the treatment and asked about their gastrointestinal

symptoms. The symptoms were recorded in the checklists provided and the data were analyzed by SPSS version 13 using

Chi-square, paired t-test, independent t-test, Mann-Whitney U test, and repeated measures.

This double-blind, randomized, controlled, clinical trial was conducted on 82 patients with


1.08) and 1.15(SD=1.00) respectively, suggesting that the difference between the two groups was statistically significant

(P=0.019). In addition, the mean changes of distension in group A(1.21, SD=0.97) were significantly higher than group B

(0.73, SD=1.06)(P=0.01). However, there were not any significant differences in the relapse of most of their symptoms

after stopping the therapy in the third week of follow-up.

At the end of the first week of follow-up, the mean changes of flatulence in groups A and B were 1.73(SD=


gastrointestinal diseases. On the other hand, dimethicone is also useful in reducing froth in the lumen of the

gastrointestinal tract. Nevertheless, in some studies dimethicone does not exhibit any beneficial effects on the symptoms

of intestinal gas. In addition, our results show that the effect of carmint is significantly higher than that of dimethicone on

relieving flatulence symptoms, especially in a short period.

Carminatives are among the oldest known remedies and were reportedly used by Hippocrates for
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Type of Study: Research | Subject: Internal Medicine

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