per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
1
9
article
Application of the competing risk model to identify factors influencing survival time in colorectal cancer
Ahmad Reza Baghestani1
baghestani.ar@gmail.com
1
Soraya Moamar
moamersoraya@yahoo.com
2
Mohamad Amin Pourhoseingholi
amin_phg@yahoo.com
3
Ali Akbar Khaden Maboudi
amaboudi@sbmu.ac.ir
4
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background and Objective: Colorectal cancer is the most common cancer of digestive system in Iran.The incidence of this cancer has increased in recent years.The aim of this study was to evaluate the survival rate and to define the prognostic factors in Iranian colorectal cancer patients using competing risk model.
Materials and Methods: Data recorded from 1060 patients with colorectal cancer who registered in Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences (Tehran, Iran) from 2004 to 2015 in a retrospective study. Analysis was performed using competing risks model. Software used for data analysis was STATA, and significance level was regarded as 0.05.
Results: The result indicated that, at the end of follow-up, 380 (35.8%) death was from colorectal cancer and 49 (4.6%) death was due to other diseases and 631 patients (59.5%) survived till the end of the study. The mean survival time for a patient in 1060 was 56.96±1.46 month with median equals 45.5 months. According to competing-risks method, only age at diagnosis and body mass index has a significant effect on patient’s survival time.
Conclusion: : In order to identify the prognostic risk factors on the survival of patients with colorectal cancer, in presence of competing risks, using the competing risk regression model was found more efficient compared to cox regression model.
http://rjms.iums.ac.ir/article-1-4692-en.pdf
Competing risk
Survival time
Colorectal cancer
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
10
20
article
Comparison of IgE-Reactivity of Aspergillus fumigatus, Aspergillus flavous and Aspergillus niger with type 1 hypersensitive patients’ sera
ebrahimimn@yahoo.com
1
mehrabanfalahati@yahoo.com
2
m-roudbary@yahoo.com
3
somayehghanbari@yahoo.com
4
k.mokhtarian@yahoo.com
5
mj.khoshmirsafa@hotmail.com
6
rezafalak@yahoo.com
7
a_s_salek@yahoo.ca
8
Background: Aspergillus species has crucial role in respiratory allergy. This study was aimed to evaluate the pattern of IgE-mediated immune response to common aspergillus species including Aspergillus fumigatus, Aspergillus flavous, Aspergillus niger in type I aspergillus-hypersensitive patients’ sera.
Methods: The prepared protein extract of Aspergillus species were dialyzed and the protein concentrations were measured by Bradford method. The protein patterns were checked by SDS-PAGE. The allergic patients and controls were selected based on their clinical history and skin prick test (SPT) results. The cross-reactivity of allergens were determined by ELISA and Western-blotting using allergic patients’ and controls’ sera.
Results: SDS-PAGE showed that the molecular weight of most of aspergillus proteins are between 11-100 kDa with typical bands between 46-100 kDa. ELISA showed that there is a significant difference between the serum-immunoreactivity of patients and negative controls for each of studied species. However, we did not find significant difference between the immunoreactivity of the patients with the studied fungal species. Western-blotting also detected various typical IgE-reactive proteins for each of aspergillus species.
Conclusion: The IgE-reactive pattern of aspergillus species shows a slight difference. The variation of the immunoreactivity of the aspergillus species could be due to the genetic variations, difference in the environmental predisposition with saprophyte molds or non-equal allergenic potency of the extracts.
al IgE-reactive proteins for each of aspergillus species.
Conclusion: The IgE-reactive pattern of aspergillus species shows a slight difference. The variation of the immunoreactivity of the aspergillus species could be due to the genetic variations, difference in the environmental predisposition with saprophyte molds or non-equal allergenic potency of the extracts.
http://rjms.iums.ac.ir/article-1-4235-en.pdf
Type 1 hyper sensitive
Aspergillus species
Western blotting
ELISA
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
21
30
article
Impact of aquatic training on immunity Responses of CRP and C3, C4 Complement Proteins in Patients with Rheumatoid Arthritis
fatemeh asghari
f.asghari1367@yahoo.com
1
asghar tofighi
a.tofighi@mail.urmia.ac.ir
2
seyyed mostafa seyyed mardani
m.mardani@gmail.com
3
Uremia University, Uremia, Iran
Uremia University, Uremia, Iran
Uremia University of Medical Sciences, Uremia, Iran
Background: Exercise training is associated with improved health outcomes in many populations. It is assumed that exercise activities in the rheumatoid arthritis (RA) population may be reduced as a result of symptoms of the disease. The purpose of this study is survey of long-term effect of regular exercise on inflammatory changes in the RA population. Methods: In a randomized control trial, 30 women with RA randomly assigned to either an exercise (15 patient) and control groups (15 patient), respectively. 8-week program of exercise intensity was 65-75% of maximum heart rate exercise three days per week, each session a period 60 minutes were conducted. A fasting blood sample was collected 24 hours prior to, after 8 weeks and after 2 month of aerobic training from the patients. levels of C-reactive protein, complement proteins C3 and C4 were measured using standard methods. Analyze data at the level of alpha error of 5% was performed using SPSS version 17.
Results: Results showed that there was a significant decline in levels of CRP and C4 after 12 weeks of regular in exercise group, but not in the control group. In this research About C3 level no significant difference was observed between the control group and exercise group.
Conclusion: These findings showed that aerobic training could reduce inflammation in patients with RA and consequently plays an important role in preventing the occurrence of cardiovascular disease in these patients.
Keywords: Rheumatoid arthritis, Exercise training, acute phase proteins, Women
http://rjms.iums.ac.ir/article-1-3165-en.pdf
Rheumatoid arthritis
Exercise training
acute phase proteins
Women
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
31
42
article
Effects of time courses of treadmill training in tissue toxicity induced by Different doses of doxorubicin in multiple organs
kamal Sadat-Hoseini
kamalsadathosainy@yahoo.com
1
Valiollah Dabidi Roshan
vdabidiroshan@yahoo.com
2
Mohadese ShojaeiShahrokhababdi
m_shojai82@yahoo.com
3
University of Mazandaran, Babolsar, Iran
University of Mazandaran, Babolsar, Iran
Tarbiat Modares University, Tehran, Iran
Background: The aim of this study was to investigate the pretreatment effects of time courses of training and different doses of medication in multiple organs (liver and heart) of rats treated with doxorubicin (DOX).
Methods: in this experimental study, Seventy-two Wistar male rats were randomly assigned to control and training groups with three subgroups: DOX 10mg/kg, DOX 20mg/kg and saline. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20 m/min, 5 days/week for 6 and 3 weeks. DOX and saline injection was performed 24 hr after the last exercise session, and tissue collection was done 24 hr after the injections.
Results: Acute administration of DOX 20mg/kg, caused a significant increase in Heat Shock Protein (HSP) and significant decrease in Catalase (CAT) and difference between two tissue (liver and heart) was significant. Six and three weeks training before DOX 20 mg/kg and DOX 10 mg/kg administration led to insignificant and significant increase in HSP, in the liver and heart, respectively. In addition, six weeks training before administration of different doses of DOX, led to significant increase in CAT in both tissue. Also, there was significant difference between two tissues after six and three weeks training.
Conclusion: The results of the present study represent that regular aerobic exercise, by increasing protective and antioxidant markers, can be prescribed as a pretreatment strategy against DOX-induced tissue toxicity (liver and heart).
http://rjms.iums.ac.ir/article-1-4227-en.pdf
Doxorubicin
Aerobic exercise
Tissue toxicity
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
43
51
article
Evaluation of X-radiation beam quality characteristics of experimental and simulated surface
gholamreza Ataei
golamrezaatae@yahoo.com
1
mahboubeh khadem abolfazli
Kourosh_gorji@yahoo.com
2
hamedbabapour@yahoo.com
3
ali shabestani monfared
monfared1345@gmail.com
4
babol university of medical science,Para medical school
One of the most common methods used in radiation therapy for the treatment of superficial skin lesions using the ortho-voltage radiation X (the kVp 300), respectively. One of the most important indicators for the treatment of this type of device, the quality of the X-ray output is usually half the thickness of the absorption (HVL) Vanrzhy show photons effective. However, in this study, the coefficient of homogeneity was examined as a factor. Materials and Methods: In this study, the half-absorption layer (HVL) and homogeneity coefficient of the X-ray surface voltage was determined kV180 experimental and simulated with Monte Carlo method and the results were compared with the EGSnrc code. Using the measured absorption curve for this exposure through the layers of the weakening of the clinic was drawn with appropriate interpolation of the curve, the half-absorption layer (HVL) and homogeneity coefficient, respectively. The package EGSnrc, the code BEAMnrc to simulate photon and electron transfer up to receive daily intravaginal and BEAMDP for coefficient homogeneity systematically and draw the output spectrum (using data from phase space code BEAMnrc) and the code DOSXYZnrc to trace the curve of percentage depth dose the water phantom was used. The results show that the mean percentage difference between the HVL and homogeneity coefficient obtained from simulation and experiment 2, 96/4% and 01/3%, respectively. Conclusion: According to previous studies that measured HVL of difference between experimental and simulated 2% to over 10% were reported as the mean difference between the 96/4%, respectively. The difference is that this is reasonable. Homogeneity coefficient was calculated from the above previous reports due to differences in the code is justified. Considering the limitations of the clinics, the present method because of the simplicity of the layout and the similarity of the clinical conditions seem to have good performance.
http://rjms.iums.ac.ir/article-1-3236-en.pdf
Homogeneity coefficient
HVL
EGSnrc
Monte Carlo simulation
ortho-voltage X-ray
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
52
67
article
A scientific review on Hadrontherapy
Seyed Mohammad Javad Mortazavi
mmortazavi@sums.ac.ir
1
Seyed Mohamad Amin Hosseini
hosseini_sma@sums.ac.ir
2
Seyed Bijan Jia
jiabijan@gmail.com
3
Seied Rabi Mahdavi
srmahdavi@hotmail.com
4
Alireza Mehdizadeh
alireza.mehdizadeh@gmail.com
5
Shiraz University of Medical Sciences, Shiraz, Iran
Shiraz University of Medical Sciences, Shiraz, Iran
University of Bojnord, Bojnord, Iran
Iran University of Medical Sciences, Tehran, Iran
Shiraz University of Medical Sciences, Shiraz,
Despite major progress in radiotherapy, exponential attenuation of initial photons due to the nature of their interaction with matter has remained as the most important challenge. Photons have no well-defined range and their doses are reduced exponentially. Therefore, tissues located before and after the tumors receive a significant dose. Today, new techniques based on proton and carbon charged particle beams have been developed in many radiotherapy centers around the world. These charged particles have a high density of ionization at the end of their ranges and most of their energy is released at the end of the path which appears as a peak with a sharp final descent called Bragg peak. Physical advantages for therapeutic purposes, such as well-defined range and the absence of exit dose have made charged particles as very good tool for delivering higher physical dose to the cancerous tissues while lower dose to surrounding healthy tissue. In addition to superior physical properties, the charged particles also possess favorable radiobiological properties which increase tumor control probability. However, some unwanted doses from secondary neutrons and photons found in areas far from the target tissue is an ongoing concern. Until the 1990s, treatment with proton beams was done only in research centers. Afterwards, hospital-based centers started using charged particles for clinical purposes. With increasing development of these centers, the overall cost of treatment is somewhat reduced and this trend is continuing with the construction of new centers
http://rjms.iums.ac.ir/article-1-4708-en.pdf
Hadrontherapy
Radiotherapy with proton and carbon ions
Dose delivery systems
Medical accelerators.
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
68
76
article
Monitoring of Urinary Iodine Status among Children Aged 8-10 Years of Iran University Medical Sciences In 2015
Faranak RahimiByranvand
fk_rahimi@yahoo.com
1
Leila Farzad
leila_farzad@yahoo.com
2
Tanaz Shoaei
shoaeit@ymail.com
3
Ahmad JoneidiJafary
jonidi.a@iums.ac.ir
4
Masoumeh Goshtaei
fgoshtaei@gmail.com
5
GP, MPH, Vice chancellor of Health, Department of Population, Family Health, Nutrition and Schools, Iran University of Medical Sciences, Tehran, Iran
BS of Nutrition, Vice chancellor of Health, Department of Population, Family Health, Nutrition and Schools, Iran University of Medical Sciences, Tehran, Iran
MSc of Nutrition, Vice chancellor of Health, Department of Population, Family Health, Nutrition and Schools, Iran University of Medical Sciences, Tehran, Iran
PhD, Professor of Environmental Health, Department of Environmental Health Engineering, School of Health, Iran University of Medical Sciences, Tehran, Iran
PhD of Health Policy, Vice chancellor of Health, Department of Health Education and Promotion, Iran University of Medical Sciences, Tehran, Iran
Abstract
Aim: Iodine deficiency disorders have been underlied the production and distribution of Iodinated salt programmers. Considering of accounting for urinary iodine evaluation in high risk groups importance in our country from a few decades ago, our study was conducted to prevent iodine deficiency disease among 8-10 years old students in 2015 in Iran university medical sciences.
Procedures: In this descriptive analytical study, 240 students of both sexes aged 8-10 inhabitant in urban and rural provinces were selected randomly by cluster sampling. All iodine excretion samples were measured according to ministry of health guidelines through acidic digestion.
Findings: In our study the average of urinary iodine was good in %78.3 of students. However, it was reported less than 10 (µg/L) in %5.4 of children. Therefore iodine deficiency distribution was divided by in two levels of slight and moderate including 4.16 and 1.25 percent, respectively. Urinary iodine median difference was insignificant for sex (p-value = 0.36), in urban and rural provinces (p-value = 0.63) and in different health centers and networks (p-value = 0.074).
Conclusions: Urinary iodine excretion median levels was reported 180.49 (µg/L) that showed desirable amounts of excretion iodine median among students.
http://rjms.iums.ac.ir/article-1-4019-en.pdf
Iodine deficiency
Urinary Iodine
Iodinated salt
students
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
77
85
article
Antidepressant- like effect of essential oil of Lavandula angustifolia Mill and Citrus bigaradia Duh with forced swimming test in reserpinized mice Balb/C.
Fariba Hashemi Shahraki
mis.hashemi50@gmail.com
1
Abdul Rasul Namjoo
AR.NAMJO72@GMAIL.COM
2
Abdollahi Ghasemi Pirbalout
ghasemi@iaushk.ac.ir
3
zahra lorigooini
rafieian@yahoo.com
4
Mahmoud Rafieian-Kopaei
rafieian@yahoo.com
5
Mostafa Gholami Arjenaki
rafieian@yahoo.com
6
MSc in Animal Physiology, Department of Animal Physiology, School of Basic Sciences, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran
Associate Professor of Veterinary pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord branch, Islamic Azad University, Shahrekord, Iran
Associate Professor of Medicinal Plants, Department of Medicinal Plants, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Assistant Professor of Pharmacognosy, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Professor of Pharmacology, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
MSc in Animal Physiology, Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Background: Levandula angustifolia and Citrus aurantium essential oils possess phenolic compounds and in Iranian traditional medicine are commonly used as sedative. The aim of this study was to evaluate the antidepressant activities of Levandula angustifolia and Citrus bigaradia in adult reserpinized mice.
Methods: In this experimental study, mice were divided into 10 groups of 8 mice each, including: Group 1, control group received normal saline. Group 2, was treated reserpine (5 mg/kg, IP). Group 3, 4, 5 and 6 were treated with reserpine (5 mg/kg, IP) and four Citrus aurantium different doses (25, 50, 100, 200 mg/kg). Group 7, 8 and 9 were treated with reserpine (5 mg/kg, IP) and three Levandula angustifolia doses (25, 50, 100 mg/kg). Group 10 was treated with reserpine (5 mg/kg, IP) and imipramine (15 mg/kg). In all groups the forced swimming test was done and the level of malondialdehyde (MDA) in brain tissue was measured to estimate the oxidative stress status. Data were analyzed by one-way ANOVA and Tukey post hoc test.
Results: Levandula angustifolia, Citrus aurantium and imipramine in reserpinized mice caused the mice to spend less time in the forced swimming test, compared to the control group (p<0.01). Also Citrus aurantium with dose of 50 and 100 mg/kg and Lavandula angustifolia with dose of 25 and 50 mg/kg in reserpinized mice reduced immobility time and levels of MDA compared the control group (p<0.01).
Conclusion: Lavander and Citrus aurantium essential oils have considerable antidepressant activity which might be attributed to their antioxidant effects.
http://rjms.iums.ac.ir/article-1-4045-en.pdf
Depression
Forced swimming test
Levandula angustifolia
Citrus aurantium
Mice Balb/C
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
86
95
article
The effect of hypnotherapy on death anxiety inpatients with acute myeloid leukemia
fatemeh fathi
fatemeh_fathi67@yahoo.com
1
ghasem janbabai
janbabai@yahoo.com
2
mehdi pourasghar
me_pourasghar@yahoo.com
3
Background: Cancer is primarily a genetic disease and Myeloid dysplasia refers to a group of syndromes thathave a close relationship with each other and through the proliferation of arbitrary one or more types of bone marrow cells, are identified. One of the most prevalent psychiatric symptoms in patients with cancer, transplantand anxiety, is death anxiety. This type of anxiety can be viewed as one of the important psychological diagnosis in patients with suspected cancer. This study aimed to investigate the effect of hypnosis ondeath anxiety in patients with acute myeloid leukemia treated with chemotherapy.
Methods: The research method was quasi-experimental with pre-test and post-test in experimental and control groups. Twenty-fourpatients with acute myeloid leukemia on chemotherapy with medical records and flow cytometry test were selected and randomly divided in experimental (n = 13) and control group (13 case). Death Anxiety Inventory Collet-Lesterinwas used to collect data from two group before and after trial. Six sessions of hypnotherapywas conducted for the experimental group in six weeks. SPSS₂₂ was used for statistical analysis of data
Results: The results showed that hypnotherapysignificantly reduces the anxiety duedeath, dead people, see people dying and death anxiety in general, which has been statistically significant (p<0.001).
Conclusion: As a result, it can be said that hypnosis is an effective intervention on the anxiety of death in patients with acute myeloid leukemia underchemotherapy and can be used as a non-invasive method
http://rjms.iums.ac.ir/article-1-4270-en.pdf
Acute myeloid leukemia
Anxiety death
Chemotherapy
Hypnotherapy
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
96
104
article
An Epidemiological study on influenza-like syndrome: Desciping reported cases to the influenza surveillance system in Hamadan province from 2013 to 2014
manoochehr.khondabi@gmail.com
1
man.karami@yahoo.com
2
gh.roshanaei@umsha.ac.ir
3
man.karami@yahoo.com
4
man.karami@yahoo.com
5
man.karami@yahoo.com
6
man.karami@yahoo.com
7
Background: The flu is a severe and fatal disease with a potential for widespread outbreaks. To reduce the social and economic costs of the disease, vaccination of the entire population and the population at risk is effective. Since every region has a sub-type of influenza virus is endemic, it is necessary to identify the species of native studies done in each area.
Methods: In this study, all data related to the flu in the health center of the province in 2013 and 2014 was collected, analyzed, and information such as: gender, occupation, type of admission, date of sampling, sample type, quality samples of the virus, the subtype of the virus and the name of the city was carried out using STATA software package version 11 data analysis was done.
Results: Of 206 cases of flu-like illness recorded in 2012, 26 confirmed cases of influenza were detected, which all (100%) belong to type A, subtype H3N2. In 2013, from 244 cases recorded flu-like illness, 44 were confirmed cases of influenza. Thirty one cases of those were type A including 18 cases of subtype H3N2 and 13 cases of H1N1 subtype. Other cases in 2013 (13 cases) were type B.
Conclusions: subspecies recommended by the World Health Organization for the 2013-2014 with the species identified in the province are consistent and can be used to provide the appropriate vaccine relied on this report.
http://rjms.iums.ac.ir/article-1-4236-en.pdf
Influenza
Epidemiology
Vaccine
Type
Serotype
per
Iran University of Medical Sciences
Razi Journal of Medical Sciences
2228-7043
2228-7051
2017-01
23
151
105
113
article
Evaluation of morphology and immunophenotype of mesenchymal stem cells after switching of bovine serum of media to human serum
Hajar Shafaei
shafaei49@gmail.com
1
Ebrahim Esfandiari
esfandiari@med.mui.ac.ir
2
Hassan Baghernezhad
hbager1389@yahoo.com
3
Department of Anatomical Sciences, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Bonyan Cellular Kosar Company, East Azarbaijan Science and Technology Park, Tabriz, Iran.
Background: Mesenchymal Stem Cells (MSCs) are used for cell therapy purposes. Fetal Bovine Serum (FBS) in culture media is essential for growth. As FBS may induce an immunological reaction and transfer pathogenic agents to MSC recipients, this study was designed to evaluate Adipose Tissue Stem Cells (ASCs) in FBS, human serum, switching of FBS to human serum and vice versa by cytology and flow cytometry.
Results: ASCs isolated and expanded in medium containing FBS were flat shape and slowly growing versus to those grown in medium containing human serum. The forward scatter data significantly demonstrated ASCs in FBS had large size as compared to others (p<0.05). Morphology of ASCs were similar to flow cytomertic findings. There are no significant differences in immunophenotypic markers of ASCs such as CD44, and CD90 grown in different media. However mean fluorescence intensity was higher for CD44 in human serum groups.
Conclusion: These results indicate that medium enriched with human serum improved the culture condition of ASCs in comparison with medium enriched with commercially available FBS. Switching of FBS to human serum may be a useful method for stem cells that are grown in medium containing FBS or frozen in FBS
http://rjms.iums.ac.ir/article-1-2467-en.pdf
Human serum
FBS
MSC
ASC