Razi Journal of Medical Sciences
مجله علوم پزشکی رازی
RJMS
Medical Sciences
http://rjms.iums.ac.ir
39
journal39
2228-7043
2228-7051
en
jalali
1398
2
1
gregorian
2019
5
1
26
2
online
1
fulltext
fa
بررسی ارتباط سطح سرمی ویتامین OH-D25 و اختلالات شناختی در سالمندان
Evaluation the relationship between serum level of vitamin D and cognitive impairment in elderly patients
مغز و اعصاب
Neurology
پژوهشي
Research
<strong><span style="color:#0070C0;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">زمینه و هدف: </span></span></span></strong><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">کمبود ویتامین </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> یک اختلال شایع در سالمندان میباشد که کمبود آن ممکن است با اختلال شناختی ارتباط داشته باشد. هدف از انجام مطالعه </span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">بررسی ارتباط </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">25 OH</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> ویتامین </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> و اختلالات شناختی در سالمندان میباشد.</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"></span></span></span><br>
<strong><span style="color:#0070C0;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">روش کار:</span></span></span></strong><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> در این مطالعه </span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">موردی- شاهدی 35 فرد مبتلا به اختلال شناختی با 35 فرد که اختلال شناختی نداشتند بررسی شدند. سطح سرمی </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">25 OH</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> ویتامین </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> در هر دو گروه بهصورت ناشتا به روش </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;"> ELISA</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">اندازهگیری شد. سطح ویتامین </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> کمتر از</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">ng/ml </span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">30 ناکافی و بیشتر از آن کافی در نظر گرفته شد. دادها با استفاده از چکلیستی که شامل اطلاعات دموگرافیک و سطح سرمی ویتامین </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> در دو گروه بود جمعآوری و با نرمافزار </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">SPSS</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> 16 تجزیه و تحلیل شد.</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"></span></span></span><br>
<strong><span style="color:#0070C0;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">یافتهها:</span></span></span></strong> <span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">میانگین سنی گروه شاهد </span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">78/4</span></span></span><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">±</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">91/67 سال و گروه مورد 63/3</span></span></span><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">±</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">91/68 سال بود (</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">328/0</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">p=</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">). میانگین سطح سرمی </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">25 OH</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> ویتامین</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;"> D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">گروه شاهد </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">ng/ml</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> 28/37 و گروه مورد </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">ng/ml</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> 06/23 بود که اختلاف مشاهده شده از نظر آماری معنیدار بود (</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">003/0</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">p=</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">). 20 نفر (1/57%) از گروه شاهد و 10 نفر (6/%) از گروه مورد سطح کافی ویتامین </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> داشتند (</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">01/0</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">p=</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">). نسبت شانس وقوع اختلال شناختی در افراد گروه مورد 3/3 برابر بیشتر از افراد گروه شاهد بود که این تفاوت نیز معنیدار بود (</span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">001/0</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">p=</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">).</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;"></span></span></span></span><br>
<strong><span style="color:#0070C0;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;">نتیجه‏ گیری:</span></span></span></strong><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> افراد سالمند مبتلا به اختلال شناختی نسبت به افراد سالم سطح سرمی ویتامین </span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">D</span></span></span></span><span style="color:black;"><span style="font-family:b mitra;"><span style="font-size:10.0pt;"> کمتری دارند که این کمبود ممکن است با اختلال شناختی آنها ارتباط داشته باشد. بااینحال تأیید نتایج این مطالعه نیازمند مطالعات آتی با حجم نمونه بیشتری میباشد.</span></span></span>
<strong>Background:</strong> Vitamin D deficiency is a common disorder in elderly, previously suggested to be associated with cognitive impairment. This study was aimed to determine the association between 25(OH) vitamin D and cognitive impairment in the elderly.<br>
<strong>Methods:</strong> In this case-control study, 35 individuals who met criteria of cognitive impairment were examined against 35 individuals who did not have cognitive impairment. Serum 25(OH) vitamin D levels were measured in both fasting groups by ELISA kits. Data were collected using a checklist containing demographic data and serum vitamin D levels in two groups and analyzed using SPSS 16 software.<br>
<strong>Results:</strong> The mean age of the control group was 67.91±4.78 years and of the case group was 68.91±3.63 years (p=0.328). The mean serum level of 25(OH) vitamin D in the control and case groups was 37.28 ng/ml and 23.06 ng/ml, respectively. The observed difference was statistically significant (p=0.003). 20 (57.1%) of control group and 10 (28.6%) of case group had sufficientlevels of vitamin D (p=0.01). The odds ratio of cognitive impairment in the case group was 3.3 times higher than control group, which was also statistically significant (p=0.001).<br>
<strong>Conclusion:</strong> Elderly people with cognitive impairment have lower levels of vitamin D than healthy ones with same age, which may be related to their cognitive impairment. However, confirmation of the results of this study requires further studies with a larger sample sizes.<br>
ویتامین D ,اختلال شناختی ,سالمندان
Vitamin D,Cognitive impairment, Elderly
30
38
http://rjms.iums.ac.ir/browse.php?a_code=A-10-3999-1&slc_lang=fa&sid=1
Masoud
Ghiasian
مسعود
غیاثیان
Masoud_ghiasian@yahoo.com
3900319475328460044935
3900319475328460044935
No
Hamedan University of Medical Sciences, Hamedan, Iran
دانشگاه علوم پزشکی همدان، همدان، ایران
Sajjad
Daneshyar
سجاد
دانشیار
s.danshyar72@yahoo.com
3900319475328460044936
3900319475328460044936
Yes
Hamedan University of Medical Sciences, Hamedan, Iran
دانشگاه علوم پزشکی همدان، همدان، ایران
Elahe
NouruzBeigi
الهه
نوروزبیگی
s.danshyar72@yahoo.com
3900319475328460044937
3900319475328460044937
No
Hamedan University of Medical Sciences, Hamedan, Iran
دانشگاه علوم پزشکی همدان، همدان، ایران
farzaneh
asna ashari
فرزانه
اثنی عشری
esna_f@yahoo.com
3900319475328460044938
3900319475328460044938
No
Hamedan University of Medical Sciences, Hamedan, Iran
دانشگاه علوم پزشکی همدان، همدان، ایران