Razi Journal of Medical Sciences
مجله علوم پزشکی رازی
RJMS
Medical Sciences
http://rjms.iums.ac.ir
39
journal39
2228-7043
2228-7051
en
jalali
1392
9
1
gregorian
2013
12
1
20
114
online
1
fulltext
fa
اثرات محافظتی عصاره گل گیاه ازگیل ژاپنی بر ضایعه القاء شده با تزریق درون بطنی 6- هیدروکسی دوپامین در موش های صحرایی نر
Protective effects of Eriobotrya Japonica flower extracts against intraventricular 6-hydroxydopamine-induced lesion in male rats
فیزیولوژی ورزش
Exercise Physiology
پژوهشي
Research
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">زمینه و هدف</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">:
استرس اکسایشی با تحلیل نورون دوپامینی در بیماری پارکینسون، مشارکت دارد. این
مطالعه با هدف بررسی اثر محافظتی عصاره گل گیاه ازگیل ژاپنی بر ضایعه القاء شده با
تزریق درون بطنی6- هیدروکسی دوپامین </span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><font face="Times New Roman"><span style="mso-spacerun: yes"> </span>(6-OHDA)</font></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">در
موش های صحرایی نر انجام شد.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">روش کار</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">:
در این مطالعه تجربی، 27 سر موش صحرایی به طور تصادفی به سه گروه کنترل، ضایعه
دیده و ضایعه دیده تحت تیمار با عصاره تقسیم شدند. ضایعه با تزریق محلول </span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span>6-OHDA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> به داخل بطن راست مغز حیوانات ایجاد شد. ضایعه دیده وضایعه دیده
تحت تیمار با عصاره ابتدا به صورت درون صفاقی به مدت دوازده هفته، هر هفته سه بار
به ترتیب سالین و عصاره (200 میلی گرم به ازای هر کیلوگرم وزن بدن) دریافت کردند،
سپس با تزریق </span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span>6-OHDA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> به داخل بطن راست مغز پارکینسونی و نهایتاً پنج روز بعد از تزریق
داخل بطنی، نمونه برداری و سطوح دوپامین و تیروزین هیدروکسیلاز جسم مخطط مغز حیوان
با روش </span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">ELISA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> اندازه گیری شد. دادهها به روش تجزیه و
تحلیل واریانس یک طرفه مورد مقایسه قرارگرفت.</span><span lang="FA" style="font-family: "B Mitra" mso-bidi-language: FA mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">یافتهها:</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 13pt mso-bidi-language: FA"> </span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتایج
نشان داد که مصرف عصاره به طور معنی داری از کاهش سطح دوپامین در جسم مخطط مغز موشهای
ضایعه دیده جلوگیری می کند (001/0</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">p=</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>)،
اما سطح تیروزین هیدروکسیلاز در گروه ضایعه تحت تیمار عصاره تغییر نکرد (86/0</span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr">p=</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span>).</span><span lang="FA" style="font-family: "B Mitra" font-size: 12pt mso-bidi-language: FA mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl text-justify: kashida text-kashida: 0%" dir="rtl"><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">نتیجه</span></b><b><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-size: 10.0pt" dir="ltr"></span></b><b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">گیری</span></b><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt">:
نتایج این پژوهش نشان داد که پیش درمانی با مصرف مزمن عصاره گل گیاه ازگیل ژاپنی
می تواند سبب محافظت نورونهای دوپامینرژیک در برابر ضایعه ناشی از </span><span dir="ltr"></span><span style="font-family: "Times New Roman","serif" font-size: 9pt mso-bidi-font-family: "B Mitra" mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span>6-OHDA</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> میشود و احتمالاً می تواند نقش حفاظتی در برابر بیماری پارکینسون
داشته باشد.<o:p /></span></p><font face="Times New Roman" size="3"> </font>
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt mso-bidi-language: FA">Background: </span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Oxidative
stress contributes to dopamine cell degeneration in Parkinson’s disease (PD)<span dir="rtl"></span><span lang="AR-SA" dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3">.</font></span><span dir="ltr"></span><span dir="ltr"></span> This study was performed with the aim<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span>of studying the
protective effects of Eriobotrya japonica<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span>flower extract<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span><span dir="ltr"></span><span dir="ltr"></span>(EJFE) on
intraventricular 6-hydroxydopamine-induced lesion in male rats<span dir="rtl"></span><span lang="AR-SA" dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3">.</font></span><o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Methods</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">: In this
laboratory experimental study, twenty seven rats were divided into three
groups: control, lesioned and extract treated lesioned. Lesion was induced with
injection of 250 mg/kg of intraventricullar 6-hydroxydopamine (i.c.v. 6-OHDA).
Lesioned and extract treated lesioned groups received saline and extract (200
mg/kg) three times per week for 12 weeks, intraperitoneally. Five days after
i.c.v. 6-OHDA injection, tyrosine hydroxylase and dopamine levels in the
striatum were measured by ELISA method. Data was analyzed using one-way
analysis of variance (ANOVA).<span lang="AR-SA" dir="rtl"><o:p /></span></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Results:</span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt"> Results show
that consuming the<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span>extract
significantly prevented the decrease in dopamine levels in Parkinson rats (p=
0.001), but tyrosine hydroxylase level did not change in the extract group (p=
0.86).<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-justify: inter-ideograph tab-stops: right 7.3pt center 265.9pt"><b><span style="font-family: "Times New Roman","serif" font-size: 12pt">Conclusions: </span></b><span style="font-family: "Times New Roman","serif" font-size: 12pt">The results of
this research showed that<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span>pre-treatment<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span>with
hydro alcoholic extraction of Eriobotrya japonica protected the dopaminergic
neurons<span dir="rtl"></span><span dir="rtl"><span dir="rtl"></span><font face="Times New Roman" size="3"> </font></span>against
6-OHDA lesion and may have protective role against Parkinson disease.<o:p /></span></p><font face="Times New Roman" size="3"> </font>
عصاره گل گیاه ازگیل ژاپنی، پارکینسون، دوپامین، موش صحرایی
Eriobotrya japonica flower extract, 6-hydroxydopamine, Rat
35
41
http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1477&slc_lang=fa&sid=1
Mohammad
Aghasi
محمد
آقاسی
3900319475328460024448
3900319475328460024448
No
University of Mazandaran, Babolsar
دانشگاه مازندران، بابلسر
Akbar
Hajizadeh Moghaddam
اکبر
حاجی زاده مقدم
3900319475328460024449
3900319475328460024449
Yes
University of Mazandaran, Babolsar
دانشگاه مازندران، بابلسر
Zia
Fallah Mohammadi
ضیاء
فلاح محمدی
3900319475328460024450
3900319475328460024450
No
University of Mazandaran, Babolsar
دانشگاه مازندران، بابلسر