Razi Journal of Medical Sciences
مجله علوم پزشکی رازی
RJMS
Medical Sciences
http://rjms.iums.ac.ir
39
journal39
2228-7043
2228-7051
en
jalali
1392
8
1
gregorian
2013
11
1
20
113
online
1
fulltext
fa
تأثیر ترکیبی تمرین اختیاری و مصرف عصاره آلیوم پارادوکسوم بر سطوح آمیلوئید بتا (Aβ1-42) پلاسمای موشهای صحرایی دیابتی
The combined effect of voluntary wheel running and Allium paradoxum on plasma Amyloid beta1-42 levels of diabetic rats
فیزیولوژی ورزش
Exercise Physiology
پژوهشي
Research
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-autospace: mso-layout-grid-align: none" dir="rtl"><b><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">زمینه و هدف:</span></b><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> پروتئین آمیلوئید بتا(</span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr">Aβ</span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span>) به عنوان یک عامل خطرساز بیماری آلزایمر در بیماران
دیابتی افزایش مییابد. هدف از تحقیق حاضر بررسی اثر ترکیبی 6 هفته تمرین اختیاری
و مصرف عصاره گیاه آلیوم پارادوکسوم بر سطوح آمیلوئید بتا<font size="2"><font face="B Mitra"><span style="mso-spacerun: yes"> </span>پلاسمای موشهای صحرائی دیابتی تحریکشده با
آلوکسان بود.<o:p /></font></font></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-autospace: mso-layout-grid-align: none" dir="rtl"><b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-font-family: "B Mitra"" dir="ltr"><!--stripped--><font size="2"> </font><!--stripped--></span></b></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-autospace: mso-layout-grid-align: none" dir="rtl"><b><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman"">روش کار</span></b><span dir="ltr"></span><b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-font-family: "B Mitra"" dir="ltr"><span dir="ltr"></span>:</span></b><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span> در این مطالعه تجربی آزمایشگاهی 28
سر موش صحرایی نر نژاد ویستار به وزن 1</span><span lang="FA" style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA">±</span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> 185 گرم، به طور تصادفی در 4 گروه (هر گروه 7 سر) کنترل،
ورزشی، آلیوم و ترکیبی تقسیم شدند. آزمودنیها با تزریق آلوکسان (120 میلی گرم بر
کیلوگرم) محلول در بافر سالین به صورت درون صفاقی، دیابتی شدند<font size="2"><font face="B Mitra"><span style="color: black">. </span>موشهای گروههای تمرین به مدت 6 هفته در قفسهای
مجهز به چرخ دوّار و به صورت اختیاری به فعالیت پرداختند. آمیلوئید بتا به روش
ایمنی سنجی آنزیمی (الایزا) اندازه گیری شد. از تحلیل واریانس یک طرفه و آزمون
تعقیبی </font></font></span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr">LSD</span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span> برای مقایسه گروهها و بررسی معنی داری یافته ها استفاده
گردید.<o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-autospace: mso-layout-grid-align: none" dir="rtl"><b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr"><!--stripped--><font size="2"> </font><!--stripped--></span></b></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-autospace: mso-layout-grid-align: none" dir="rtl"><b><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">یافتهها:</span></b><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"> میزان </span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr">Aβ<sub>1-42</sub></span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span> پلاسمای گروه ورزشی<font size="2"><font face="B Mitra"><span style="color: black"> نسبت به گروه کنترل به طور معنیداری </span>افزایش یافت (</font></font></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-fareast-font-family: "Times New Roman"">001/0</span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra" mso-fareast-font-family: "Times New Roman"" dir="ltr">P=</span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span>). همچنین میزان </span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr">Aβ<sub>1-42</sub></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">پلاسمای <font face="B Mitra"><font size="2"><span style="color: black">گروه </span>ترکیبی<span style="color: black"> نسبت به گروه</span>های کنترل (</font></font></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-fareast-font-family: "Times New Roman"">029/0</span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra" mso-fareast-font-family: "Times New Roman"" dir="ltr">P=</span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span>)<font size="2"><font face="B Mitra"><span style="color: black"> و آلیوم </span>(</font></font></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-fareast-font-family: "Times New Roman"">025/0</span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra" mso-fareast-font-family: "Times New Roman"" dir="ltr">P=</span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span>)افزایش یافت. با
این وجود، تفاوت معنیداری بین سطوح </span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr">Aβ<sub>1-42</sub></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">پلاسمای <font size="2"><font face="B Mitra"><span style="color: black">گروه </span>ترکیبی با گروه تمرین (</font></font></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-fareast-font-family: "Times New Roman"">210/0</span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra" mso-fareast-font-family: "Times New Roman"" dir="ltr">P=</span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span>) و آلیوم با گروه کنترل (</span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-bidi-language: FA mso-fareast-font-family: "Times New Roman"">944/0</span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra" mso-fareast-font-family: "Times New Roman"" dir="ltr">P=</span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span>) مشاهده نشد. <o:p /></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-autospace: mso-layout-grid-align: none" dir="rtl"><b><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr"><!--stripped--><font size="2"> </font><!--stripped--></span></b></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify unicode-bidi: embed direction: rtl text-autospace: mso-layout-grid-align: none" dir="rtl"><b><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">نتیجهگیری:</span></b><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">سطوح پلاسمائی </span><span style="line-height: 115% font-family: "Times New Roman","serif" font-size: 10pt mso-bidi-language: FA mso-bidi-font-family: "B Mitra"" dir="ltr">Aβ<sub>1-42</sub></span><span dir="rtl"></span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA"><span dir="rtl"></span> آزمودنیهای دیابتی به دنبال تمرین
اختیاری و مصرف عصاره گیاه آلیوم پارادوکسوم افزایش </span><span lang="AR-SA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: Lotus">یافت. به نظر میرسد </span><span lang="FA" style="line-height: 115% font-family: "B Mitra" font-size: 10pt mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-bidi-language: FA">برای درک آثار
مثبت یا منفی این افزایش بر عوارض ناشی از بیماری دیابت به تحقیقات بیشتری نیاز
است.<o:p /></span></p><font face="Times New Roman" size="3"> </font>
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 10pt text-align: justify line-height: normal"><font size="3"><b><span style="font-family: "TimesNewRoman,Bold","serif" mso-bidi-font-family: "TimesNewRoman,Bold"">Background:</span></b><span style="font-family: "Times New Roman","serif"">Amyloid-beta (Aβ), is one of the
risk factors of Alzheimer’s disease (AD) that increases in diabetes. </span></font><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"><font size="3">The aim of
this study was to investigate the effect of 6 weeks of voluntary wheel running
with Allium paradoxum supplementation on plasma Amyloid beta</font><sub><font size="2">1-42</font></sub><font size="3"> in
the diabetic rats induced with Alloxan.<o:p /></font></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: normal text-autospace: mso-layout-grid-align: none"><font size="3"><b><span style="font-family: "TimesNewRoman,Bold","serif" mso-bidi-font-family: "TimesNewRoman,Bold"">Methods:</span></b><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"> In this
laboratory experimental study 28 male ratsweighing 185±1 gm were randomly
assigned to 4 groups: control, training, Allium, and Allium-training. Diabetes
was induced with injecting Alloxan (120 mg/kg dissolved in saline)
peritoneally. </span><span style="font-family: "Times New Roman","serif"">The
traininggroup participated in voluntary wheel running for 6 weeks.<o:p /></span></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 10pt text-align: justify line-height: normal"><b><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"><!--stripped--><font size="3"> </font><!--stripped--></span></b></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 10pt text-align: justify line-height: normal"><b><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"><font size="3">Results:</font></span></b><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"><font size="3">Sixweeks of
voluntary wheel running significantly increased the plasma Aβ</font><sub><font size="2">1-42 </font></sub><font size="3">levels
in training group compared with control group (P<0.001). Also Aβ</font><sub><font size="2">1-42</font></sub><font size="3">
levels increased in training-Allium group in comparison with control group
(P=0.029) and Allium (P=0.025). Nevertheless, plasma Aβ</font><sub><font size="2">1-42 </font></sub><font size="3">levels
was not different between training-Allium and training (P=0.210) and Allium
(P=0.944) groups.<font face="Times New Roman"><span style="mso-spacerun: yes"> </span><span lang="FA" dir="rtl"><o:p /></span></font></font></span></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 10pt text-align: justify line-height: normal"><b><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"><font size="3">Conclusion:</font></span></b><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"><font size="3">The plasma
Aβ</font><sub><font size="2">1-42 </font></sub><font size="3">levels of diabetic subjects <span style="mso-spacerun: yes"><font face="Times New Roman"> </font></span>was increased following 6 weeks of voluntary</font></span><span style="font-family: "Times New Roman","serif""><font size="3"> exercise combined with Allium
Paradoxum extract supplementation, but understanding the beneficial effects of
this increase in plasma </font></span><span style="font-family: "Times New Roman","serif" mso-bidi-language: FA"><font size="3">Aβ</font><sub><font size="2">1-42</font></sub><font size="3"> levels</font></span><font size="3"><span style="font-family: "Times New Roman","serif""> requires more studies.</span><span lang="FA" style="font-family: "Times New Roman","serif" mso-bidi-language: FA" dir="rtl"><o:p /></span></font></p><font face="Times New Roman" size="3"> </font>
آلیوم پارادوکسوم، Aβ1-42 پلاسما، تمرین اختیاری چرخ دوّار.
Allium paradoxum, Plasma Aβ1-42, Voluntary wheel running.
29
37
http://rjms.iums.ac.ir/browse.php?a_code=A-10-1-1466&slc_lang=fa&sid=1
Zia
Fallah mohammadi
ضیاء
فلاح محمدی
3900319475328460024788
3900319475328460024788
No
Mazandaran University
دانشگاه مازندران، بابلسر
Mojtaba
Ebrahimzadeh
مجتبی
ابراهیم زاده
3900319475328460024789
3900319475328460024789
Yes
Mazandaran University
دانشگاه مازندران، بابلسر
Alireza
Safaiee
علیرضا
صفایی
3900319475328460024790
3900319475328460024790
No
Mazandaran University
دانشگاه مازندران، بابلسر