TY - JOUR JF - RJMS JO - RJMS VL - 26 IS - 4 PY - 2019 Y1 - 2019/7/01 TI - Application of CuO nano particle/multi-walled carbon nanotube nanocomposite modified electrode for simultaneous determination of dopamine and rutin in real samples TT - الکترود کربن شیشه ای اصلاح شده با نانو لوله های کربنی چند جداره دوپ شده با نانو ذرات اکسید مس به عنوان نانو کامپوزیت جدید برای تعیین همزمان دوپامین و روتین در نمونه های فیزیولوژیکی حقیقی N2 - Background: In this work, a new method was developed for simultaneous determination of dopamine and rutin at glassy carbon electrode modified with CuO nanoparticles doped multi-walled carbon nanotubes (CuONPs–MWNT/GCE). This modified electrode has shown excellent electrocatalytic activity toward the oxidation of rutin in acetate buffer solution (pH=5). The modified electrode lowered the overpotential of the reaction by ~500 mV, and this advantage of modified electrode made it aproprate to measure trace values of dopamine in the presence of rutin. Methods: First, the electrochemical behavior of CuO nanoparticles, incorporated in the modified electrode, was studied. Then, the behavior of oxidation of rutin and dopamine at the modified electrode was investigated by differntial puls voltammetry. Results: A linear calibration plot was obtained over the range of 0.05-580 µmol L–1 rutin and 0.09-600 μmol L–1 for dopamine. Detection limits of 0.013 µmol L–1 rutin and 0.021 μmol L–1 dopamine were obtained. The relative standard deviation of ten replicate measurements for rutin and dopamine was measured 1.2% and 1.53% respectively. Conclusion: The high sensitivity, low detection limit and reproducibility of the modified electrode, made the proposed electrode suitable for the determination of dopamine in the presence of rutin in pharmaceutical samples SP - 22 EP - 31 AU - Rohani, Tahereh AD - Payame Noor University, Tehran, Iran KW - Rutin KW - Dopamine KW - Electrocatalytic oxidation KW - CuO nanoparticles KW - Multi-walled carbon nanotubes UR - http://rjms.iums.ac.ir/article-1-5407-en.html ER -