TY - JOUR T1 - A review on the Authism with the most approach on the critical biomarkers TT - مروری بر بیماری اوتیسم با رویکردی بر مهمترین نشانگرهای زیستی JF - RJMS JO - RJMS VL - 24 IS - 165 UR - http://rjms.iums.ac.ir/article-1-4857-en.html Y1 - 2018 SP - 35 EP - 46 KW - Autism KW - Biomarkers KW - Brain N2 - In recent years, more attention has been given to some childhood neurological disorders like include autism. Autism is a disorder that causes difficulties to language skills, the performance of social skills, and represents repetitive, stereotypic movements and non-functional behaviour patterns. During the 1970s, the prevalence of autism in the United States ranged from 1 to 3 in 10,000. In the early 21st century the prevalence of autism has reached 1 in 150. As the high prevalence and increasing tendency of the prevalent, there is an urgent need to identify the pathophysiological mechanisms that could explain the social behavioral impairments in autism in a unify way. Identifying of biomarkers that have important role in the diagnosis of autism can provide fast and accurate diagnosis and more effective treatments for autistic patients. As autism contains a wide spectrum disorders and the main involved mechanisms are not clear, this study was aimed to review pathophysiological mechanisms, treatments, diagnostic assessments and biomarkers of autism. Because treatment of peoples who suffer also from autism is a contemporary challenge, it is hoped that by identifying of biomarkers for autism, new and effective therapeutic targets will be achieved. M3 ER -