TY - JOUR T1 - The Interaction between CETP Taq1B Polymorphism and Dietary Fat Intake on HDL-c according to lipid profile status in T2DM Patients TT - ارتباط متقابل پلی مورفیسمCETP Taq1Bو مقدار چربی دریافتیبر سطحHDL-cبا توجه به وضعیت پروفایل لیپیددر افراد مبتلا به دیابت نوع 2 JF - RJMS JO - RJMS VL - 23 IS - 149 UR - http://rjms.iums.ac.ir/article-1-4183-en.html Y1 - 2016 SP - 98 EP - 108 KW - lipid disorder KW - CETP Taq1B polymorphism KW - dietary fat intake KW - HDL-c KW - type 2 diabetes N2 - Background and objectives: Dyslipidemia is a major problem in T2DM causing atherosclerosis diseases. We investigated the relationship between CETP Taq1B polymorphism and HDL-c concentrationsconsidering dietary fat intake in Tehranian dyslipidemic and normolipidemic T2DM patients. Material and methods: In the presentcross-sectional study 184 T2DM patients were investigated. We used FFQ questionnaire, anthropometric measurements and biochemical tests. PCR-RFLP was used todetermine polymorphism. We performed Chi-square and ANOVA and ANCOVA for statistical analysis. Results: The frequency of B1B1 genotype was significantly different according to patients’ lipid profile status (P=0.01). There was no significant relationship between genotype and HDL-c concentrations. The interaction between CETP Taq1B polymorphism and total fat intake was significant in normolipidemic patients (Pinteraction= 0.02). There were no such a relationship in dyslipidemic patients. In addition, patients with B2B2 genotype and low total fat intake had significantly higher HDL-c concentrations in comparison with B1B1 genotype (P=0.03). Conclusion: Patients with B1B1 genotype were more likely to be dyslipidemic. The relationship between CETP Taq1B polymorphism and HDL-c concentrationswas affected by dietary total fat intake in normolipidemic T2DM patients. M3 ER -