%0 Journal Article %A kalantar, Zahra %A Mahmoodi, Maryam %A sotodeh, Gity %A Mansoori, Anahita %A Djalali, Mahmoud %A Eshraghian, Mohamad Reza %A koohdani, Fariba %T The Interaction between CETP Taq1B Polymorphism and Dietary Fat Intake on HDL-c according to lipid profile status in T2DM Patients %J Razi Journal of Medical Sciences %V 23 %N 149 %U http://rjms.iums.ac.ir/article-1-4183-en.html %R %D 2016 %K lipid disorder, CETP Taq1B polymorphism, dietary fat intake, HDL-c, type 2 diabetes, %X Background and objectives: Dyslipidemia is a major problem in T2DM causing atherosclerosis diseases. We investigated the relationship between CETP Taq1B polymorphism and HDL-c concentrationsconsidering dietary fat intake in Tehranian dyslipidemic and normolipidemic T2DM patients. Material and methods: In the presentcross-sectional study 184 T2DM patients were investigated. We used FFQ questionnaire, anthropometric measurements and biochemical tests. PCR-RFLP was used todetermine polymorphism. We performed Chi-square and ANOVA and ANCOVA for statistical analysis. Results: The frequency of B1B1 genotype was significantly different according to patients’ lipid profile status (P=0.01). There was no significant relationship between genotype and HDL-c concentrations. The interaction between CETP Taq1B polymorphism and total fat intake was significant in normolipidemic patients (Pinteraction= 0.02). There were no such a relationship in dyslipidemic patients. In addition, patients with B2B2 genotype and low total fat intake had significantly higher HDL-c concentrations in comparison with B1B1 genotype (P=0.03). Conclusion: Patients with B1B1 genotype were more likely to be dyslipidemic. The relationship between CETP Taq1B polymorphism and HDL-c concentrationswas affected by dietary total fat intake in normolipidemic T2DM patients. %> http://rjms.iums.ac.ir/article-1-4183-en.pdf %P 98-108 %& 98 %! The Interaction between CETP Taq1B Polymorphism and Dietary Fat Intake on HDL-c in T2DM Patients %9 Research %L A-10-2840-1 %+ Tehran University of Medical Sciences %G eng %@ 2228-7043 %[ 2016