AU - Sadoughi, Seyed Damoon AU - Zafar-Balanezhad, Saide AU - Baharara, Javad AU - Nejhad Shahrokhabadi, Khadijeh AU - Rahbarian, Raheleh AU - Sepehri-Moghadam, Heshmat TI - Investigating the effect of ethanolic extract of Ferula assa-foetida's resin on angiogenesis in chick chorioalantoic membrane PT - JOURNAL ARTICLE TA - RJMS JN - RJMS VO - 22 VI - 131 IP - 131 4099 - http://rjms.iums.ac.ir/article-1-3787-en.html 4100 - http://rjms.iums.ac.ir/article-1-3787-en.pdf SO - RJMS 131 AB  - Background: Inhibition of angiogenesis is the main goal of cancer treatment and other diseases. Ferula assa-foetida is a medicinal plant with cytotoxic effects. The aim of this study was to investigate the anti-angiogenic effects of Ferula assa-foetida's resin.  Methods: 40 Hy-line fertilized eggs were divided into 4 groups: control, sham, experimental 1 (treated with 100 μg/ml of extract), experimental 2 (treated with 200 μg/ml of extract). On the eighth day of incubation it was created a window in the bottom of the eggs and gelatin sponge was placed on chorioallantoic membrane. 10 microliters of Ferula assa-foetida's resin extract was injected to treated groups. 10 microliters of distilled water was injected to control group and 10 microliters of dimethyl sulfoxide was injected to sham-exposed group. All samples were photographed on the 12th day of incubation and the length and numbers of vessels were analyzed by ANOVA and Tukey’s post hoc (p>0.05)  Results: The mean of number and length for vessels in the control group and mean of number and length in sham-exposed group was not significant. There was a significant decrease in mean number and length of vessels at concentration of 100 and 200 μg/ml of Ferula assa-foetida's resin extract compared with control group. Conclusion: According to this research, ethanolic extract of Ferula assa-foetida's resin has an inhibitory effect on angiogenesis in chick chorioalantoic membrane. It seems that compounds of Ferula assa-foetida's resin can be used to inhibit angiogenesis in cancer tissues CP - IRAN IN - LG - eng PB - RJMS PG - 80 PT - Research YR - 2015