TY - JOUR T1 - The Effect of Nasturtium officinale Feeding on Serum Glucose and Lipid Levels and Reorganization of Beta Cells in Diabetic Rats TT - اثر مصرف خوراکی علف چشمه بر میزان گلوکز و چربی‌های سرم و بازسازی سلول‌های‌ بتا موش صحرایی دیابتی JF - RJMS JO - RJMS VL - 17 IS - 73 UR - http://rjms.iums.ac.ir/article-1-1477-en.html Y1 - 2010 SP - 53 EP - 61 KW - Keywords: 1) Nasturtium officinale 2) Glucose 3) Lipid 4) Diabetes mellitus 5) Rat N2 -     Background:  Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids to normal level is very important in diabetic patients. In this study, the effect of oral administration of Nasturtium officinale on serum levels of glucose and lipids, as well as morphology of Langerhans islets in diabetic rats was investigated. Methods: In this experimental study, male Wistar rats (n = 36) were divided randomly into 4 groups i.e. control, treated control, diabetic, and treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food (6.25%) for 6 weeks. Diabetes was induced in the rats by administrating a single dose of Streptozotocine (60 mg/kg, IP) Serum glucose, triglyceride, total cholesterol, LDL- and HDL- cholesterol levels were determined before the study, and at 3rd and 6th weeks after the study. Morphology of Langerhans islets in the 4 groups was evaluated using Gomori monochrome staining method. For statistical analysis of data, Repeated measurement and One-way ANOVA tests were applied using Sigma Stat .Results:� Treatment of diabetic rats did have a significant hypoglycemic effect (p M3 ER -