TY - JOUR T1 - Association between B2 Allele Frequency in CETP Gene with Low level of HDL-C in Tehran TT - ارتباط فراوانی الل 2B در ژن CETP، با میزان HDL-C در جمعیت تهرانی JF - RJMS JO - RJMS VL - 11 IS - 43 UR - http://rjms.iums.ac.ir/article-1-71-en.html Y1 - 2004 SP - 757 EP - 763 KW - Key Words: 1) Cholesterol Ester Transfer Protein(CETP) N2 - The object of the present study was to investigate the association between common CETP polymorphism, TaqI in intron 1, and high density lipoprotein levels in Tehran population. In order to examine the relationship between B2 allele and HDL-C level, 356 people with the lowest, medium and highest deciles of HDL cholesterol levels were selected out of 993 healthy subjects from TLGS. Factors known to influence HDL cholesterol level, such as smoking, body mass index and blood pressure were then studied. A segment of mentioned gene was amplified with PCR and then polymorphism was revealed with RFLP. The allele frequency distributions of the TaqI (intron1) polymorphism differed significantly between the groups with low(50mg/dl) HDL cholestrol. Homozygotes for the B1 allele had lower HDL-C levels(36±11mg/dl) than subjects carrying B2 allele(46±13mg/ml)(P M3 ER -