RT - Journal Article T1 - The Study of the Association Between Vitamin D Receptor Common Genetic Polymorphisms and Susceptibility to Pulmonary Tuberculosis JF - RJMS YR - 2009 JO - RJMS VO - 16 IS - 0 UR - http://rjms.iums.ac.ir/article-1-1263-en.html SP - 0 EP - 0 K1 - Pulmonary tuberculosis K1 - Vitamin D K1 - Vitamin D receptor K1 - Genetic polymorphism AB -   Background and Aim: In addition to exposure to Mycobacterium tuberculosis (MTB), development of tuberculosis is influenced by environmental and host genetic factors, and clinical disease only occurs in less than 10% of the infected individuals. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of mycobacterium. This effect may be influenced by polymorphisms in the vitamin D receptor (VDR) gene. In the present study we investigated the impact of VDR gene variation in susceptibility to pulmonary tuberculosis.   Materials and Methods: This study was a case-control analysis in an Iranian population. We evaluated four VDR gene polymorphisms [defined by the presence of restriction endonuclease sites for FokI (F/f), BsmI (B/b), TaqI (T/t), and ApaI (A/a)] in 96 patients with tuberculosis and 122 matched healthy controls. A modified polymerase chain reaction with sequence-specific primers (PCR-SSP) technique was used to identify these polymorphisms in VDR gene simultaneously.Chi square was used for data analysis.   Results: Comparison of allele and genotype frequencies for the above VDR gene polymorphic sites revealed no significant difference between patient and control groups.   Conclusion: This data may rule out the importance of VDR gene polymorphisms in susceptibility to tuberculosis among Iranian population. LA eng UL http://rjms.iums.ac.ir/article-1-1263-en.html M3 ER -