@ARTICLE{Tajik, author = {Tajik, N. and Jafari, M. and Nasiri, M.R. and Mousavi, T. and Farnia, P. and Salekmogaddam, A. and }, title = {The Study of the Association Between Vitamin D Receptor Common Genetic Polymorphisms and Susceptibility to Pulmonary Tuberculosis}, volume = {16}, number = {0}, abstract ={  Background and Aim: In addition to exposure to Mycobacterium tuberculosis (MTB), development of tuberculosis is influenced by environmental and host genetic factors, and clinical disease only occurs in less than 10% of the infected individuals. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of mycobacterium. This effect may be influenced by polymorphisms in the vitamin D receptor (VDR) gene. In the present study we investigated the impact of VDR gene variation in susceptibility to pulmonary tuberculosis.   Materials and Methods: This study was a case-control analysis in an Iranian population. We evaluated four VDR gene polymorphisms [defined by the presence of restriction endonuclease sites for FokI (F/f), BsmI (B/b), TaqI (T/t), and ApaI (A/a)] in 96 patients with tuberculosis and 122 matched healthy controls. A modified polymerase chain reaction with sequence-specific primers (PCR-SSP) technique was used to identify these polymorphisms in VDR gene simultaneously.Chi square was used for data analysis.   Results: Comparison of allele and genotype frequencies for the above VDR gene polymorphic sites revealed no significant difference between patient and control groups.   Conclusion: This data may rule out the importance of VDR gene polymorphisms in susceptibility to tuberculosis among Iranian population. }, URL = {http://rjms.iums.ac.ir/article-1-1263-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-1263-en.pdf}, journal = {Razi Journal of Medical Sciences}, doi = {}, year = {2009} }