TY - JOUR JF - RJMS JO - RJMS VL - 16 IS - 0 PY - 2009 Y1 - 2009/9/01 TI - Inhibitory Effect of Ziziphora Clinopodioides Lam. on Rat’s Gastric Acid Secretion in Basal, Vagotomized and Vagal Stimulated Conditions TT - اثر مهاری عصاره آبی- الکی آویشن باریک بر ترشح اسید معده موش صحرایی در شرایط پایه، واگوتومی و تحریک عصب واگ N2 -     Background & Aim: Ziziphora clinopodioides Lam. is a plant widely used in Iranian traditional medicine. Several reports have demonstrated antibacterial, antioxidant and anti-inflammatory properties of Ziziphora clinopodioides. The aim of this study is to investigate the effects of aqueous-ethanol extract of Ziziphora clinopodioides on rat’s gastric acid secretion and its probable mechanism.Material and Method: In this interventional experimental study, 24 Wistar rats weighing 200-250g were randomly divided into two groups: test and control. Tracheostomy and gastroduodenostomy procedures were performed on each rat. Gastric content was collected for 15 minutes by washout technique. 1 ml of three dosages (0. 5, 1 and 2 mg/kg) was introduced into the stomach of each rat in the test group and the same volume of saline was used in the control group. Total titratable acid was measured by a titrator. Data were shown as mean±SEM and analyzed by unpaired t-test. P SP - 0 EP - 0 AU - Niazmand, S. AU - Erfanian Ahmadpoor, M. AU - Hajzadeh, M. AU - Hosseini, Kh. AD - KW - Ziziphora Clinopodioides Lam KW - Gastric Acid KW - Vagotomy KW - Vagous Nerve UR - http://rjms.iums.ac.ir/article-1-1257-en.html ER -