AU - Izadi, F AU - Doroudinia, A AU - Shekarabi, M AU - Kavand, P AU - Heidari, N AU - Pousti, B TI - Evaluation of Cellular Immune System Activity in Patients with Head and Neck Tumors and its Relationship with Diagnosis, Stage and Prognosis of the Disease PT - JOURNAL ARTICLE TA - RJMS JN - RJMS VO - 13 VI - 53 IP - 53 4099 - http://rjms.iums.ac.ir/article-1-643-en.html 4100 - http://rjms.iums.ac.ir/article-1-643-en.pdf SO - RJMS 53 AB  -     Background & Aim: Considering the role of cellular immunity in prognosis of malignant tumors of the head and neck, especially SCCs(Squamous Cell Carcinoma), we intended to investigate cellular immune system activity in patients with head and neck tumors, whether malignant or benign, and then compare it with the kind, severity and prognosis of tumoral involvement. Patients & Method: This is a cross-sectional study performed on 40 head and neck tumor patients in Hazrat-e-Rasoul and Firouzgar hospitals from November 2003 to June 2005. After skin testing with DNCB(Dinithrochlorobanzen) and grading skin reactions, blood sampling was performed within 3 weeks and after isolating, culturing, and stimulating the lymphocytes with PHA(phytohemaggulotini) stimulant, the amount of cytokine production was measured using ELISA(Enzyme Linked Immunosorbent Assay) method. Then the results were compared with the information pertained to pathologic diagnosis, the stage of the disease, and also the results of clinical follow-up. Results: Patients with more advanced malignant tumors(stages 3&4) had weaker skin reactions compared with the early stages of the disease(10.5% contre 87.5% p CP - IRAN IN - Assistant Professor of ENT and Head & Neck Surgery. Hazrat Rasoul-e-Akram Hospital. Niayesh St., Sattarkhan Ave., Iran University of Medical Sciences and Health Services. Tehran, Iran LG - eng PB - RJMS PG - 23 PT - Research YR - 2007