TY - JOUR T1 - The Effect of Oral Clonidine Premedication on Hemodynamic Responses during Gynecologic Laparascopy under General Anesthesia TT - بررسی اثر پیش‌داروی خوراکی کلونیدین بر روی پاسخ‌های همودینامیک حین اعمال لاپاروسکوپی زنان تحت بیهوشی عموم JF - RJMS JO - RJMS VL - 13 IS - 50 UR - http://rjms.iums.ac.ir/article-1-563-en.html Y1 - 2006 SP - 39 EP - 46 KW - Key Words: 1) Clonidine 2) Remifentanil 3) Laparoscopy 4) Cis-atracurium N2 -     Background & Aim: Clonidine, an alpha 2 agonist, attenuates sympathetic responses during general anesthesia and improves the intra-operative hemodynamic stability. In this randomized double blinded clinical trial study, we report the effects of 300µg oral clonidine premedication(n=22) or placebo(n=22) on hemodynamic alteration during gynecologic laparoscopic surgery, under general anesthesia. Previous works have reported the effectiveness of clonidine on blunting the sympathetic responses during open surgeries. Patients & Methods: Anesthesia consisted of isoflurane/O2 and remifentanil. Muscle relaxation was maintained by cis-atracurium. Hemodynamic data were obtained at 5 epochs: base, after induction of anesthesia, insufflation(after peumoperitoneum, supine position), trendelenburg 30 degrees, and end(after supine extubation. Results: There was a significant increase in systolic blood pressure during peritoneal insufflation and trendelenburg position in patients in the control group(129±23, 115±29mmhg) compared with patients in the clonidine group(126±34, 116±25mmhg), P M3 ER -