RT - Journal Article T1 - INDOMETHACIN THERAPY IN SEVERE POLYHYDRAMNIOS JF - RJMS YR - 2002 JO - RJMS VO - 8 IS - 26 UR - http://rjms.iums.ac.ir/article-1-378-en.html SP - 411 EP - 413 K1 - 1) Polyhydramnios 2) Preterm delivery 3) Indomethacin AB - Polyhydramnios is defined as excessive accumulation of amniotic fluid. It is associated with inceased incidence of abruptio placenta, preterm birth, cord prolopse and neonatal death (30%). So in this clinical trial, 12 pregnant women with significant polyhydramnios (AFI> 24 cm) and gestational age of 24-32 weeks, received oral Indomethacin at a dose of 100 mg/day for 8 days. AF volume decreased in all patients (P=0.000). We didn’t observe any maternal and fetal-neonatal side effect due to indomethacin therapy. Mean gestational age at delivery was 37.7 ± 1 weeks. It can be concluded that short term indomethacin therapy is effective in significant polyhydramnios without any maternal and fetal side effect.  LA eng UL http://rjms.iums.ac.ir/article-1-378-en.html M3 ER -