TY - JOUR JF - RJMS JO - RJMS VL - 8 IS - 23 PY - 2001 Y1 - 2001/6/01 TI - EFFECT OF HYDROXYUREA ON FETAL HEMOGLOBIN PRODUCTION AND FREQUENCY OF PAINFUL CRISES IN SICKLE CELL ANEMIA TT - بررسی تاثیر هیدروکسی اوره بر میزان تولید هموگلوبین جنینی و فراوانی حملات دردناک در کم‌خونی سلول داسی شکل N2 -   Hydroxyurea (HU) enhances the production of fetal hemoglobin (HbF) and on the other hand this event can decreases the frequency of painful crises in sickle cell anemia (SCA). We studied the efficiency of HU in reducing painful crises and it’s effect on HbF production rate and on other hematologic values in 40 SCA patients. Median age of patients was 20 years. Eighteen were male and 22 were female.   Duration of study was 2 years. In the first year, patients were under observation without HU but were on folic acid 1mg/d and necessary data collected, then HU started at a dosage of 20-25 mg/kg/day in adition to folic acid and continued for one year.   Among treated patients with HU,HbF level increased significantly in 70% of patients (mean 4% vs 10.8%, p SP - 92 EP - 97 AU - Vakili, M. AU - Yavarian, M. AD - KW - 1) Sickle cell anemia 2) Hydroxyurea 3) Fetal hemoglobin UR - http://rjms.iums.ac.ir/article-1-316-en.html ER -