@ARTICLE{Vosadi, author = {Vosadi, Elham and Barzegar, Hamed and Borjianfard, Mahboobe and }, title = {The effect of omega-3 supplementation and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus}, volume = {21}, number = {119}, abstract ={Background: This study was to examine the effects of omega-3 supplementation and high-fat diet in brain-derived neurotrophic factor (BDNF) in the male adult rat hippocampus. Methods: Twenty one Wistar rats were divided into three groups: (1) regular diet (RD), (2) high-fat (HF) diet and (3) Docosahexaenoic acid (DHA) diet. RD group was regarded as control. Animals in HF groups were exposed to the HF diet for 8 weeks and animals in DHA groups were treated with 100/mg/kg/day of DHA via oral gavage for 8 weeks. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data was analyzed by one-way ANOVA. When appropriate, further differences were analyzed by LSD post hoc test. Statistical differences were considered significant at p<0.05. Results: The results showed that the HF diet had no significant effect in BDNF protein level (p=0.873), while the DHA diet revealed a significant increase in BDNF protein level comparison with the RD (p=0.008) and HF (p=0.006) group Conclusion: According to results of the present study, DHA diet can increase the amount of hippocampus BDNF protein level. }, URL = {http://rjms.iums.ac.ir/article-1-3101-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-3101-en.pdf}, journal = {Razi Journal of Medical Sciences}, doi = {}, year = {2014} }