RT - Journal Article T1 - The combined effect of voluntary wheel running and Allium paradoxum on plasma Amyloid beta1-42 levels of diabetic rats JF - RJMS YR - 2013 JO - RJMS VO - 20 IS - 113 UR - http://rjms.iums.ac.ir/article-1-2779-en.html SP - 29 EP - 37 K1 - Allium paradoxum K1 - Plasma Aβ1-42 K1 - Voluntary wheel running. AB -  Background:Amyloid-beta (Aβ), is one of the risk factors of Alzheimer’s disease (AD) that increases in diabetes. The aim of this study was to investigate the effect of 6 weeks of voluntary wheel running with Allium paradoxum supplementation on plasma Amyloid beta1-42 in the diabetic rats induced with Alloxan. Methods: In this laboratory experimental study 28 male ratsweighing 185±1 gm were randomly assigned to 4 groups: control, training, Allium, and Allium-training. Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) peritoneally. The traininggroup participated in voluntary wheel running for 6 weeks.   Results:Sixweeks of voluntary wheel running significantly increased the plasma Aβ1-42 levels in training group compared with control group (P LA eng UL http://rjms.iums.ac.ir/article-1-2779-en.html M3 ER -