@ARTICLE{Ebrahimzadeh, author = {Fallah mohammadi, Zia and Ebrahimzadeh, Mojtaba and Safaiee, Alireza and }, title = {The combined effect of voluntary wheel running and Allium paradoxum on plasma Amyloid beta1-42 levels of diabetic rats}, volume = {20}, number = {113}, abstract ={ Background:Amyloid-beta (Aβ), is one of the risk factors of Alzheimer’s disease (AD) that increases in diabetes. The aim of this study was to investigate the effect of 6 weeks of voluntary wheel running with Allium paradoxum supplementation on plasma Amyloid beta1-42 in the diabetic rats induced with Alloxan. Methods: In this laboratory experimental study 28 male ratsweighing 185±1 gm were randomly assigned to 4 groups: control, training, Allium, and Allium-training. Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) peritoneally. The traininggroup participated in voluntary wheel running for 6 weeks.   Results:Sixweeks of voluntary wheel running significantly increased the plasma Aβ1-42 levels in training group compared with control group (P }, URL = {http://rjms.iums.ac.ir/article-1-2779-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-2779-en.pdf}, journal = {Razi Journal of Medical Sciences}, doi = {}, year = {2013} }