TY - JOUR T1 - Effect of psychosocial stress on the testosterone concentration and pain perception in male rats TT - اثر استرس روانی- اجتماعی بر غلظت تستوسترون و درک درد در موش های نر JF - RJMS JO - RJMS VL - 17 IS - 78 UR - http://rjms.iums.ac.ir/article-1-1603-en.html Y1 - 2010 SP - 18 EP - 24 KW - Psychosocial stress KW - Pain KW - Testosterone KW - Rat N2 -   Background: Animal models of psychosocial stress are a good model for studying stress-related behavioral and endocrinological disorders in humans. The aim of present study is to investigate the effect of psychosocial stress on plasma testosterone level and pain perception.   Methods: In this experiment 74 male rats (200-250 g) and 20 female rats (200-300 g) were used. In experimental groups ( S1,S2), subjects were exposed to the attacks of stimulus (dominant) rats once a day for 5 consecutive days (30 min VS 4 hr). In control groups, subjects and stimulus rats were housed in different rooms (C1) or in adjacent cages in a room (C2). Pain perception was assessed by means of the Tail flick test. Testosterone was measured by radio-immunoassay. SPSS V.11 statistical software was used for data analysis. One way ANOVA was used to evaluate the results.   Results: Psycho-social stress reduced testosterone concentration in subject groups (S1, S2). Tail flick latency decreased significantly in S2 subject group (TFL: 4.2±0.4 s) and C2 control group (TFL: 4.2±0.2 s) as compared to C1 control group (TFL: 5.9 ± 0.8s). In addition there was significant difference between two subject groups (p M3 ER -