@ARTICLE{Zareian, author = {Dakhesh, S and Zareian, P and }, title = {Effect of psychosocial stress on the testosterone concentration and pain perception in male rats}, volume = {17}, number = {78}, abstract ={  Background: Animal models of psychosocial stress are a good model for studying stress-related behavioral and endocrinological disorders in humans. The aim of present study is to investigate the effect of psychosocial stress on plasma testosterone level and pain perception.   Methods: In this experiment 74 male rats (200-250 g) and 20 female rats (200-300 g) were used. In experimental groups ( S1,S2), subjects were exposed to the attacks of stimulus (dominant) rats once a day for 5 consecutive days (30 min VS 4 hr). In control groups, subjects and stimulus rats were housed in different rooms (C1) or in adjacent cages in a room (C2). Pain perception was assessed by means of the Tail flick test. Testosterone was measured by radio-immunoassay. SPSS V.11 statistical software was used for data analysis. One way ANOVA was used to evaluate the results.   Results: Psycho-social stress reduced testosterone concentration in subject groups (S1, S2). Tail flick latency decreased significantly in S2 subject group (TFL: 4.2±0.4 s) and C2 control group (TFL: 4.2±0.2 s) as compared to C1 control group (TFL: 5.9 ± 0.8s). In addition there was significant difference between two subject groups (p }, URL = {http://rjms.iums.ac.ir/article-1-1603-en.html}, eprint = {http://rjms.iums.ac.ir/article-1-1603-en.pdf}, journal = {Razi Journal of Medical Sciences}, doi = {}, year = {2010} }