TY - JOUR T1 - Incidence of Central Nervous System Involvement in Childhood Malignancies in Hazrat-e-Ali Asghar Childrens Hospital from 1998 to 2008 TT - تعیین بروز درگیری سیستم اعصاب مرکزی در بدخیمی‌های دوران کودکی در بیمارستان کودکان حضرت علی اصغر(ع) از سال 1382 تا 1387 JF - RJMS JO - RJMS VL - 17 IS - 76 UR - http://rjms.iums.ac.ir/article-1-1525-en.html Y1 - 2010 SP - 30 EP - 35 KW - Keywords: 1) Childhood malignancies 2) CNS metastasis 3) Neuroblastoma N2 -     Background: Contrary to adults, primary and metastatic involvement of CNS is a rare condition in pediatric malignant tumors. With CNS involvement the prognosis will be poor and practical treatment modalities will decline so new approaches must be reviewed. The aim of this study was to find out the incidence of CNS involvement in different childhood malignancies. Also the survival analysis was determined.Methods: This study is a cross-sectional project conducted on children with different extra CNS malignancies with metastases to CNS in a 10 year period from 1998 to 2008. These children were admitted in Hematology and Oncology ward of Hazrat-e-Ali Asghar Childrens hospital. CNS involvement was diagnosed by radiological (invasion of dura by tumor) or clinical evidences. Data were analyzed by Chi square and t-tests SPSS v> 17 was also used. P M3 ER -