Volume 26, Issue 10 (12-2019)                   RJMS 2019, 26(10): 1-7 | Back to browse issues page

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Kazemi-Lomedasht F, Behdani M, Shahbazzadeh D. Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line. RJMS 2019; 26 (10) :1-7
URL: http://rjms.iums.ac.ir/article-1-5707-en.html
Pasteur Institute of Iran, Tehran, Iran , fa_kazemi@pasteur.ac.ir
Abstract:   (2550 Views)
Background: Breast cancer is one of the most related cancer deaths among women. The scorpion venom consists of various peptides and proteins with cytotoxic, apoptotic and growth inhibitory effects on various cancers. Studying the cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line was the main aim of this study.
Methods: The T47D cells were cultured as monolayer in RPMI1640 medium. The toxicity of the scorpion venom on T47D cell line was evaluated by MTT assay and the IC50 was calculated. The HEK293 cell line was used as control cell line. Results: The MTT assay results showed the time and dose-dependent inhibitory effect of H. lepturus venom on T47D cell line. However, such effect was not observed on HEK293 cell line in identical dose.
Conclusion: The achieved results indicate the anticancer effect of H. lepturus venom on T47D breast cancer cell line.
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Type of Study: Research | Subject: Biology

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