Volume 26, Issue 11 (1-2020)                   RJMS 2020, 26(11): 0-0 | Back to browse issues page

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Gheibi Hajivar F, sazgar H, zia jahromi N. Effect of Silymarin on plasma concentration of TNF-α and serum albumin inflammatory factor in streptozotocin-induced diabetic rats. RJMS. 2020; 26 (11)
URL: http://rjms.iums.ac.ir/article-1-5586-en.html
Shahrekord Branch, Islamic Azad University, Shahrekord, Iran , hoseinsazgar@yahoo.com
Abstract:   (914 Views)
Aim and Background: Inflammation is a multiphasic pathophysiological process in which many inflammatory mediators such as histamine, bradycin, prostaglandins, and inflammatory cytokines, such as tumor necrosis factor alpha and interleukins, are involved. In this study, the effects of silymarin on inflammatory factors of TNF-α and albumin-phase proteins in type 1 diabetic rats were investigated.
Material and methods: A total of 42 adult male rats were divided into seven groups of six. For streptozotocin judgment, diabetes mellitus was used (Rats for 100 to 110 g / kg body weight, 50 mg / kg Streptococcus). It should be noted that the healthy group did not receive any effective drugs or drugs. The control group received only Silicon Marin. After the end of the period of blood transfusion, the amount of tumor necrosis factor alpha and albumin was measured.
Results: The results showed that TNF-α levels of 150 mg / kg in rats receiving silymarin resulted in a significant reduction in the reduction of alpha-tumor necrosis factor and also increased albumin levels. The statistical analysis of the data in the albumin variable indicates that serum albumin levels in rats receiving 150 mg / kg body weight, metformin, the group receiving silymarin and the healthy group with the negative control group have a significant relationship. The results showed that the level Serum albumin was not associated with negative control in treated rats at 100 mg / kg and 50 mg / kg (P <0/06).
Conclusion: The present study showed that rats with diabetes versus healthy rats had elevated levels of inflammatory mediators such as alpha and albumin tumor necrosis factor in blood plasma, as well as silymarin at 150 mg / Has had an effect on the improvement of the rats.
Type of Study: Research | Subject: Biochemistry

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