Volume 25, Issue 166 (4-2018)                   RJMS 2018, 25(166): 20-33 | Back to browse issues page

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Rajabi A, Siahkouhian M, Akbarnejad A. Comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women. RJMS. 2018; 25 (166) :20-33
URL: http://rjms.iums.ac.ir/article-1-4930-en.html
PhD candidate in Exercise Physiology, Faculty of Education and Psychology Faculty of Physical Education and Sport Sciences, University of Tehran
Abstract:   (617 Views)
Background: The purpose of this study was comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women
Methods: 48 type 2 diabetic obese women were randomly divided into four equal groups (saffron + training, training + placebo, saffron, placebo). The saffron group + training and training + placebo groups performed aerobic training with intensity of 60-75% of maximal heart rate for 8 weeks (three sessions per week). Daily dose of 400 mg of Saffron sprout powder (once a day) was used for two months. The placebo contained 400 mg of wheat flour. The following IL-6, TNF-a, Blood glucose and HbA1c variables; lipid profiles and HOMA-IR were tested. The Shapiro-Wilk test, variance analysis with repeated measures, Bonferron's post hoc test, and one way analysis of variance with LSD post-test.
Results: In the post-test phase, the pre-test the variables IL-6 and TNF-α, blood glucose and HbA1c in intervention groups decreased significantly, and also in the post-test between group, saffron + training with training + placebo, saffron + training  with saffron, saffron + training  with placebo and saffron with placebo there was a significant difference (p<0.05). Also, in variables of weight and BMI, there were statistically significant differences between saffron + training with placebo groups, training + placebo with placebo groups, and saffron with the placebo groups (p<0.05).
Conclusion: It can be possible aerobic exercise and saffron consumption have a protective effect against the increased levels of blood glucose and HbA1c. It is possible that the reduction of blood glucose, IL-6 and TNF-a in saffron recipients is due to the presence of saffron metabolites, especially flavonoids (crostein and crocin) and increased antioxidant defense system through saffron.
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Type of Study: Research | Subject: Sports Medicine

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