Volume 26, Issue 1 (4-2019)                   RJMS 2019, 26(1): 0-0 | Back to browse issues page

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Naderpoor germi M, Mousavi aghdas M, Tvassoli K. The effect of a single dose of intravenous dexamethasone administered before parotid surgery, on facial nerve paralysis, randomized controlled clinical trial. RJMS. 2019; 26 (1)
URL: http://rjms.iums.ac.ir/article-1-4892-en.html
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Abstract:   (506 Views)


Weakness of the facial nerve is the major complication of parotid tumors. The aim of this study was to evaluate the effect of a single dose of intravenous dexamethasone injection before superficial parotidectomy on facial nerve dysfunction after surgery.

 Materials and Methods:

This randomized clinical trial performed on 40 patients with benign lesions of the parotid with the normal function of the facial nerve, superficial parotidectomy was performed, patients were randomly assigned to two groups of 20 patients under medication and placebo, patients of both groups underwent superficial parotidectomy. The early postoperative function and rate of return of function and its relation to the size, type and position of the mass, age, sex were compared among the groups.   


40 patients were studied in two groups, the mean age of patients in the placebo group and 9.87 ± 41.6 years in the placebo group was 13.61 ± 41.35. Incidence of postoperative facial nerve dysfunction was significantly lower in patient received Dexamethasone (5% in drug group versus 35% in placebo group) on the first postoperative day (P = 0.018). The results of the statistical analysis showed that there is no statistically significant difference between the nerve dysfunction based on the location of the mass (p = 0.749) and mass size (P = 0.505) between two groups and the nerve dysfunction rate between the two groups in terms of age (P = 0.49) and gender (P = 0.429). Dexamethasone injection 4 hours before the operation has no effect on nerve recovery time between two groups of drug and placebo (P = 0.091).


This study shows that the use of dexamethasone 4 hours before the superficial parotidectomy has a good result in the reduction of facial nerve dysfunction.

Type of Study: Research | Subject: ENT

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