Volume 24, Number 158 (8-2017)                   RJMS 2017, 24(158): 0-0 | Back to browse issues page

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Zarneshan A, Zolfaghari M, Gholamnejad M, Yousefi M. Effect of aerobic exercise training on sex hormones and markers of inflammation in asthmatic women. RJMS. 2017; 24 (158)
URL: http://rjms.iums.ac.ir/article-1-4635-en.html

PhD student in Exercise Physiology Urmia University
Abstract:   (738 Views)

After puberty, asthma becomes more prevalent and severe in women as compared to men.  Researchers are suggesting a role for sex hormones impact on inflammatory mediators. Estrogen has been shown to regulate eosinophil migration, adhesion, survival, and degranulation and promote the class switching of B cells to immunoglobulin E synthesis. Also, progesterone Elevated total IgE and eosinophilic airway inflammation by enhancing systemic IL-5 production. Increased levels of inflammatory markers, such as IL-4, IL-5, IL-13, blood eosinophils and IgE, are positively correlated with asthma severity. Physical activity decreases inflammation and sex hormone levels and improves pulmonary functions in asthmatic patients. Therefore, the aim of the present study was to investigate the effect of 12 weeks of aerobic exercise training on sex hormones and blood markers of airway inflammation in mid-luteal phase of asthmatics women.

Among the asthmatic patients, 24 women with mild to moderate asthma and regular menstrual cycles were selected and divided into two groups including experimental (n=13) and control (n=11) groups. The experimental group performed aerobic exercise training, three times a week, 60 minutes each session, and the control group remained inactive. Each training session consisted 15 minutes warm up, 30-minute walk on a treadmill with 60-80% of patients’ maximum heart rate and final 15 minutes of breathing exercises and cool-down. The training began with 60 percent of maximum heart rate in the first two weeks and the subsequent sessions were gradually increased by increasing the treadmill slope and speed. To reduce problems such as exercise-induced asthma (EIA) during exercise, American College Sports Madison (ACSM) guidelines were used. So, patients were asked to breathe through their nose as much as possible when exercising, and have long- time warm up and drink water before and after the exercise. Before and 24 hours after the last training session, estrogen, progesterone and blood inflammatory markers and also spirometry were measured in mid-luteal phase. To determine the mid-luteal phase: participant’s menstrual cycle was monitored for 3 months prior to the start of the study protocol.  Middle of the menstrual cycle was determined by Ovulation Strip Test (Max14). Seven to eight days after ovulation was determined as the mid-luteal phase. Before and 24 hours after the last training session and in mid-luteal phase, estrogen, progesterone and blood inflammatory markers were measured.

Twenty-one subjects (12 in exercise and 9 in control) completed the protocol. According to our results, there were significant differences in changes of serum IL-5 and IL4 between groups(p<0/05). After three-month exercise training, a significant correlation between the changes in serum level of progesterone and the IL-5 differences were observed (p=0/017, B=0/17, β=0/84). And there was a positive Relationship between the progesterone level with blood eosinophil percentage (r=0/61, p=0/017) and serum level of IL-5(r=0/91, p=0/001) in the exercise group at baseline. In Conclusion, the present study indicates that aerobic exercise training decreased serum levels of IL-4 and IL-5 and altering serum level of progesterone was effective in reducing IL-5 in mid-luteal phase of asthmatic women.

Type of Study: Research | Subject: Pulmonary Disease

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