Volume 23, Issue 149 (11-2016)                   RJMS 2016, 23(149): 98-108 | Back to browse issues page

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kalantar Z, Mahmoodi M, sotodeh G, Mansoori A, Djalali M, Eshraghian M R et al . The Interaction between CETP Taq1B Polymorphism and Dietary Fat Intake on HDL-c according to lipid profile status in T2DM Patients. RJMS. 2016; 23 (149) :98-108
URL: http://rjms.iums.ac.ir/article-1-4183-en.html
Tehran University of Medical Sciences , fkoohdan@tums.ac.ir
Abstract:   (2834 Views)

Background and objectives: Dyslipidemia is a major problem in T2DM causing atherosclerosis diseases. We investigated the relationship between CETP Taq1B polymorphism and HDL-c concentrationsconsidering dietary fat intake in Tehranian dyslipidemic and normolipidemic T2DM patients.

Material and methods: In the presentcross-sectional study 184 T2DM patients were investigated. We used FFQ questionnaire, anthropometric measurements and biochemical tests. PCR-RFLP was used todetermine polymorphism. We performed Chi-square and ANOVA and ANCOVA for statistical analysis.

Results: The frequency of B1B1 genotype was significantly different according to patients’ lipid profile status (P=0.01). There was no significant relationship between genotype and HDL-c concentrations. The interaction between CETP Taq1B polymorphism and total fat intake was significant in normolipidemic patients (Pinteraction= 0.02). There were no such a relationship in dyslipidemic patients. In addition, patients with B2B2 genotype and low total fat intake had significantly higher HDL-c concentrations in comparison with B1B1 genotype (P=0.03).

Conclusion: Patients with B1B1 genotype were more likely to be dyslipidemic. The relationship between CETP Taq1B polymorphism and HDL-c concentrationswas affected by dietary total fat intake in normolipidemic T2DM patients.

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Type of Study: Research | Subject: Nutrition Sciences

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