Volume 8, Number 26 (3-2002)                   RJMS 2002, 8(26): 411-413 | Back to browse issues page


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Haghighi L, Rahmani E. INDOMETHACIN THERAPY IN SEVERE POLYHYDRAMNIOS. RJMS. 2002; 8 (26) :411-413
URL: http://rjms.iums.ac.ir/article-1-378-en.html

Abstract:   (6221 Views)
Polyhydramnios is defined as excessive accumulation of amniotic fluid. It is associated with inceased incidence of abruptio placenta, preterm birth, cord prolopse and neonatal death (30%). So in this clinical trial, 12 pregnant women with significant polyhydramnios (AFI> 24 cm) and gestational age of 24-32 weeks, received oral Indomethacin at a dose of 100 mg/day for 8 days. AF volume decreased in all patients (P=0.000). We didn’t observe any maternal and fetal-neonatal side effect due to indomethacin therapy. Mean gestational age at delivery was 37.7 ± 1 weeks. It can be concluded that short term indomethacin therapy is effective in significant polyhydramnios without any maternal and fetal side effect. 
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