Volume 23, Issue 142 (4-2016)                   RJMS 2016, 23(142): 11-19 | Back to browse issues page

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Karimi S, Tahghighi A. A review to theimportance of quinolone ring in achieving new anti-malarial drugs. RJMS. 2016; 23 (142) :11-19
URL: http://rjms.iums.ac.ir/article-1-3769-en.html
Assistant Professor, Malaria and Vector Research Group (MVRG), Biotechnology Research Center (BRC) Pasteur Institute of Iran, Tehran, Iran
Abstract:   (1504 Views)

Malaria is an acute and chronic disease caused by obligate intracellular protozoan parasites of the genus plasmodium, transmitted through the bite of female anopheles mosquitoes. According to the World Health Organization (WHO) report, currently malaria transmits in 104 countries and due to a failure in the fight against this disease, their control and elimination is difficult. The parasite resistance to current and inexpensive drugs is one of the difficulties in the way of the elimination of malaria.  Furthermore, achievement to a new drug with different mechanism of action is inevitable.In this respect, research groups focused on heterocyclic rings to find new drugs with different mechanism of action compared to current drugs. So, they synthesized various derivatives and evaluated their antimalarial activity on different stages of the parasite’s life cycle. The compounds containing quinolone ring with diverse substituents on ring presented suitable activity on blood, liver and gametocyte stages. Furthermore, according to the tendency of these compounds on the different stages of the malaria parasite, they canbe considered as lead compound to achieve new antimalarial drugs with different mechanisms of action and evaluated further.Due to theimportance of the subject, in this review article are introduced some quinolone derivatives with antimalarial activity.

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Type of Study: review article | Subject: parasitology

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