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URL: http://rjms.iums.ac.ir/article-1-3572-en.html
Background: Sleep is a universal circadian biological rhythm which
is seen among all vertebrate and has two separate steps including REM and
Non-REM. Total or partial sleep deprivation would lead to cognitive
dysfunction. It seems that the cognitive dysfunction following sleep
deprivation is resulted from cellular changes in certain area involved in this
phenomenon. Regarding the role of hippocampus in cognitive dysfunction and
behavior and also the continuation of neurogenesis in this area, the present
research was designed to study the effects of short-term sleep deprivation on
neurogenesis in hippocampus and memory of adult male rats.
Methods: Twenty four Wistar adult male rats were used in this
study. The animals randomly divided into three groups of trials and control.
Flower pot technique was used for REM-SD. To study spatial memory Morris Water
Maze was used. In order to evaluate
neurogenesis Brdu immunohistochemistry was used. Data were analyzed using SPSS
and the results presented in the form of Mean± SD, the p < 0.05 considered
as significant.
Results: Short-term REM-SD led to significant decrease of
neurogenesis in hippocampus of trial groups comparing control group. We showed
that REM-SD significantly affected some certain parameters of memory in
REM-SD.
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