Volume 22, Issue 140 (2-2016)                   RJMS 2016, 22(140): 43-54 | Back to browse issues page

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moossavi A, faraji L. Possible role of synaptic plasticity in DCN , as factor for subjective tinnitus. RJMS. 2016; 22 (140) :43-54
URL: http://rjms.iums.ac.ir/article-1-3191-en.html
phD student Iran university of medical sciences
Abstract:   (1370 Views)

Abstaract Background and Aim: Tinnitus is a specific auditory sensitivity in which the patient hears nonexistent sounds. From neurological point of view, in majority of them increment in neural activity has been proposed characterized by increase in spontaneous firing rate in central auditory system. According to a hypothesis, tinnitus is a result of abnormal synaptic plasticity and reduced inhibitory aminoacidic NTM in auditory neural network. This compensatory reduction of inhibition to partial deafferentiation (due to hearing pathologies, acoustic trauma,…) results in elevated neural firing rate and hyperactivity mainly in fusiform cells in DCN. In this review article was Effort survey effect of DCN synaptic plasticity and tinnitus. Method: At this Review Article, some articles about synaptic plasticity and tinnitus in DCN from electronic databases of Google scholar, PubMed and Scopus and Science Direct were searched from 1988 up 2013 and some of theme select and Survey. Conclusion: DCN the lowest level of Auditory system that synaptic plasticity and hyperactivity after hearing impairment occur there. This Event tendency to tinnitus .But this Concept, not meaning to NO Cooperation of other auditory center in tinnitus. KEY WORDS :tinnitus, synaptic plasticity, Dorsal Cochlear Nucleus(DCN)

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Type of Study: review article | Subject: Oudiology

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