Volume 22, Issue 139 (1-2016)                   RJMS 2016, 22(139): 27-34 | Back to browse issues page

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Nouri S, Sharif M R, Jamali B, Panahi Y. Comparison the effect of calcium sulfate and ferric sulfate in controlling liver bleeding: an animal model study. RJMS. 2016; 22 (139) :27-34
URL: http://rjms.iums.ac.ir/article-1-3027-en.html
Trauma Research Center, Kashan University of Medical Sciences , dr.mrsharif@yahoo.com
Abstract:   (1819 Views)

Background: The control of parenchymal hemorrhage especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to compare the hemostatic effect of calcium sulfate and ferric sulfate on controlling the bleeding from liver parenchymal tissue.

Methods: In this animal model study 60 male wistar rats were used. A length of two cm and a depth of half a cm incision was made on each mouse’s liver and the hemostasis time was measured using calcium sulfate and ferric sulfate different concentrations (15%, 25%, and 50%). Finally, the obtained data were entered into SPSS software and analyzed using Kruskal-wallis test, Mann – Whitney, Kolmogorov – Smirnov and also Wilcoxon signed ranks test.

Results: In all groups we had complete hemostasis. The hemostasis time of calcium sulfate concentration groups was significantly less than that of the ferric sulfate group (p<0.01).

Conclusion: Calcium sulfate and ferric sulfate can control liver bleeding and both are effective hemostatic agents in controlling liver parenchymal tissue hemorrhage in an animal model.

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Type of Study: Research | Subject: General Surgery

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