Volume 22, Number 139 (1-2016)                   RJMS 2016, 22(139): 128-133 | Back to browse issues page


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rahimzadeh N, asllani S, hoseini R, Javadmoosavi G, javadmoosavi A. The pattern of antibiotic resistance between the years 1992 to 2013 in children with urinary tract infections admitted to Rasoul-e-Akram and Ali Asghar hospitals. RJMS. 2016; 22 (139) :128-133
URL: http://rjms.iums.ac.ir/article-1-2897-en.html

Associate Professor medical university
Abstract:   (930 Views)

Background: Urinary tract infections are very common diseases in children and E. coli is
considered as the main cause of urinary tract infections. This study aimed to determine the
prevalence of antibiotic-resistant microbial species in urinary tract infection of children
between 1370-1391 due to increasing consumption and resistance antimicrobial agents that
used commonly.
Methods: In this study, from 1992 to 2013, all patients with urinary tract infection between 2
month and under 15 years of age were enrolled.
Results: The age ranged from 2 months to 15 years with an average of 3.57-3.92 years.
Escherichia coli (E. coli) was the most common uropathogen in 253 patients (73.4%),
Klebsiella in 57 patients (24.8%) Pseudomonas in 9 patients (2.6%), Proteus in 7 patients
(3%), Acinetobacter and Enterobacter each in 1 patient (0.3%) respectively. Most of the
isolates were resistant to ampicillin (64.5%), and trimethoprim/sulfamethoxazole (61.5%).
Most of the strains were susceptible to amikacin, nitrofurantoin and Ciprofloxacin (respective
susceptibility rates, 90%, 84.5, and 72%). During this period, a significant decrease in
sensitivity was observed for ampicillin, cefotaxime and nalidixic acid (p<0.001).
Conclusion: These data suggest that trimethoprim/sulfamethoxazole may no longer be used
as empirical treatment for community-acquired UTI. In order to preserve the activity of
fluoroquinolones for future years, alternatives such as nitrofurantoin should be considered

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Type of Study: Research | Subject: Pediatric Nephrology

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