Volume 20, Number 108 (6-2013)                   RJMS 2013, 20(108): 70-77 | Back to browse issues page


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Ghaffary M R, Ansarin K, Sakhinia E, Khoramifar A R. Thrombophilia and Biological Fat of Pulmonary Embolism. RJMS. 2013; 20 (108) :70-77
URL: http://rjms.iums.ac.ir/article-1-2580-en.html

Assistant Professor of Internal Medicine Tabriz University of Medical Sciences
Abstract:   (2828 Views)

  Background: Pulmonary embolism (PE) and deep venous thrombosis (DVT) constitute one of the “big three” cardiovascular killers, along with myocardial infarction and stroke. Although thrombophilia play major and well documented role in pathogenesis of arterial and venous thromboembolism, but the effect of thrombophilia in biological fat of thromboembolism is not well recognized. The role of acquired and hereditary thrombophilia in biological fat of thromboembolism are our maine purpose in this study.

  Methods : Methods: 60 patients with diagnosed throboemboli were assessed in two groups based on genetic and acquired risk factors of thromboemboli (group A and B each with 30 patients). All cases were evaluated considering the genetic or acquired factors and the relation with pulmonary artery residual thrombosis at the beginning and 6 months after treatment and compared with each other.

  Results: 31(56.4%) patients were male and 24 (43.6%) female. The mean age was 44.4±14 in the range of 23 to 75 years. The relation between pulmonary artery clot stability and genetic factors was significant (p=0.03) but there was no correlation between pulmonary artery pressure and genetic or acquired risk factors (p=0.24).

  Conclusions: Considering the relation between genetic risk factors and the history of pulmonary thromboemboli many pulmonary complications and mortality may be avoided by preventive and therapeutic measures (as in genetic engineering) beneficial for the patients and health care system.

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Type of Study: Research | Subject: Pulmonary Disease

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