Volume 19, Issue 102 (12-2012)                   RJMS 2012, 19(102): 47-52 | Back to browse issues page


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Ahmadi R, Belbasi M, Mafi M. The effects of immobilization stress and Aloe vera aqueous extract on serum levels of SGOT and SGPT in male rats. RJMS. 2012; 19 (102) :47-52
URL: http://rjms.iums.ac.ir/article-1-2289-en.html

MSc student. Immunologist Tehran University of Medical Sciences
Abstract:   (3737 Views)
Background: Studies show that there are relations between various types of stress and liver function. The main aim of this study was to determine the effects of immobilization stress and Aloe vera extract on serum level of Serum Glutamic Pyruvic Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT) in male rats.

  Methods: In this laboratory experimental study, male Wistar rats were randomly divided into control, Aloe vera extract or normal saline receiving, under acute or chronic immobilization animals of 5 in each group. After 6 weeks blood samples were collected using cardiac puncture method. Following serum collection, SGOT or SGPT level was measured by spectrophotometry method. Data were statistically analyzed and compared between groups using ANOVA.

  Results: Serum SGOT level was significantly increased in rats enduring acute or chronic immobilization animals compared with control rats (p<0.01 and p<0.001, respectively). Serum level of SGOT level was significantly increased (p<0.01) and of SGPT was significantly decreased (P<0.01) in extract receiving animals compared with control rats (p<0.001).

  Conclusion: Our findings indicate that immobilization and Aloe vera extract is serum SGOT enhancer. In this respect, in clinical considerations, pathological effects of immobilization or Aloe vera intake is important in the field of SGOT biochemical alteration.

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Type of Study: Research | Subject: Physiology

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