Volume 18, Issue 89 (11-2011)                   RJMS 2011, 18(89): 27-33 | Back to browse issues page

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Khodabakhsh R I, Gohari M R, Moghadamifard Z, Foadzi H, Vahabi N. بقای بدون بیماری در بیماران سرطان پستان و تعیین عوامل موثر. RJMS. 2011; 18 (89) :27-33
URL: http://rjms.iums.ac.ir/article-1-1958-en.html
Assistant Professor of Biostatistics
Abstract:   (7254 Views)


Mediterean region. Disease-free survival is common to evaluate the treatment of cancers. Several

factors have been determined as prognostic factors for disease-free survival in studies.

Breast cancer is the most common cancer among women especially in eastern


in Fayazbakhsh hospital, Tehran. These patients had no metastasis at the time of diagnosis. Patients

underwent MRM or BCS surgery. All patients followed until 2011 April. Metastases were diagnosed

with x-ray, Biochemical methods, ultrasound with oncologist confirmation. A Cox’s regression with

time to first event variable was used to determine the prognostic factors. Kaplan-Myer method was

used to estimate the survival function. All statistical methods ran in R software version 2.10.

In this cross-sectional study, during 2005-2007, 153 women with breast cancer were treated


99(74.4%) without metastasis and 9 patients(6.8%) experienced a metastasis. Using Kaplan-Myer

estimation showed that disease-free survival was 64 months, and five years rate of disease-free was 72

percent. Increasing in disease-free survival was associated with low grade of tumor, low number of

involved lymph nodes, ER negative and HER2 negative. Odds ratio of metastasis or death for HER2

positive was 2.46 times of HER2 negative. Patients with grade 3 had risk of metastasis 1.69-fold of


Out of 133 patients, 25(18.8%) died and 108(81.2%) were alive. Out of alive patients,


nodes were prognostic factors. Age, size of tumor and PR were not identified as prognostic factors.

The result of this study showed that HER2, ER, Grade and number of involved lymph
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Type of Study: Research | Subject: Hematology & oncology

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