Volume 7, Issue 22 (3-2001)                   RJMS 2001, 7(22): 288-294 | Back to browse issues page


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Shafiei M. THE EFFECTS OF DISEASES ON BETA- ADRENOCEPTOR RESPONSIVENESS. RJMS. 2001; 7 (22) :288-294
URL: http://rjms.iums.ac.ir/article-1-1705-en.html

Abstract:   (3115 Views)

The development of radioligand - binding studies has greatly advanced our knowledge of the molecular pharmacology of beta - adrenoceptors. Using this technique it became possible for the first time to directly determine the tissue concentration of beta - adrenoceptors, and by this, the responsiveness of tissues to beta - adrenergic stimulation. One major insight into the molecular pharmacology of beta - adrenoceptors to come from radioligand - binding studies was that the tissue concentration of beta - adrenergic is not a fixed number, but is rather dynamically regulated by a variety of drugs, hormones, physiological and pathologic conditions.

In addition to the changes that occur in receptor characteristics, post - receptor events may be influenced by different pathologic states which in turn affect beta - adrenoceptor responsiveness.

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Type of Study: Research | Subject: Pharmacology

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