Volume 17, Number 74 (8-2010)                   RJMS 2010, 17(74): 33-42 | Back to browse issues page


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Sharafi A, Hekmat S, Mortezazadeh T, Movahed M. Measurement of the Absorbed Dose of Radiopharmaceuticals 99mTc-EC and 99mTc-DTPA by Kidney, Liver, Bladder and Ovary in Renal Scintigraphy Experiments using Water Phantom and TLD Dosimetry. RJMS. 2010; 17 (74) :33-42
URL: http://rjms.iums.ac.ir/article-1-1482-en.html

Professor of Medical Physics
Abstract:   (4523 Views)

    Background: In this survey the absorbed dose by kidneys, bladder, liver and ovaries with 99mTc-EC (99mTc Ethylene dicysteine) renal scintigraphy was measured and compared with the absorbed dose from 99mTc-DTPA (99mTc - Dietheylne Triamine Penta-Acid), which often is used in renal scintigraphy.

Methods: In this applicable study, we used a water phantom with geometrical sizes similar to that of human body and composed of thorax and hip. Then in accordance with International Committee on Radiation Protection ICRP -23, we placed kidney, liver, bladder and ovary phantoms in to the thorax and hip parts. For dosimetry 30 cubical Lithium fluoride chips (TLD-100) were used.

By using different values of 99mTc-EC and 99mTc-DTPA distributed in different phantom parts, the absorbed doses in kidneys, liver, bladder and ovaries were measured. Then by measuring skin dose in the region of kidneys, bladder, liver and ovaries in 20 female patients (10 patients for each radioisotope) that were under renal scan, the absorbed doses of above mentioned organs using phantom results were calculated. Statistical software used was SPSS V.16 and statistical data analysis was done by One sample Kolmogorov-Smirnov and t-tests.

Results: The results of skin and organ absorbed doses of kidneys, liver, bladder and ovaries showed a good linear regression. The relationship between organ dose and skin dose with total activity varied linearly. The results of organ absorbed dose in patients that were under renal scan with both radiopharmaceuticals showed:

- Bladder absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 4.42±0.98 mrad/mCi, 2.91±0.74 mrad/mCi (p=0.001).

-Liver absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 2.44±0.44 mrad/mCi, 1.58±0.019 mrad/mCi (p=0.000).

-Right kidney absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 4.04±1.06 mrad/mCi, 2.67±0.036 mrad/mCi (p=0.003).

- Left kidney absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 4.11±0.93 mrad/mCi, 2.60±0.14 mrad/mCi (p=0.000).

-Ovaries absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 2.55±0.28 mrad/mCi, 1.62±0.025 mrad/mCi (p=0.000).

Conclusion: The results of this study showed that in patients under renal scan with 99mTc-EC, absorbed dose by kidneys, liver, bladder and ovaries is considerably lower than those with 99mTc-DTPA. Also as 99mTc-EC has several other advantages such as: easily prepared, cheap, lower hepatic uptake, produces high quality images and has high renal excretion as compared to 99mTc-DTPA, thus it could be used more in radioisotopic renal scan in nuclear medicine clinics.

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Type of Study: Research | Subject: Biophysics

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