Volume 16, Issue 64 (october 2009)                   RJMS 2009, 16(64): 0-0 | Back to browse issues page


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Tajik N, Jafari M, Nasiri M, Mousavi T, Farnia P, Salekmogaddam A. The Study of the Association Between Vitamin D Receptor Common Genetic Polymorphisms and Susceptibility to Pulmonary Tuberculosis. RJMS. 2009; 16 (64)
URL: http://rjms.iums.ac.ir/article-1-1263-en.html

Abstract:   (5447 Views)

  Background and Aim: In addition to exposure to Mycobacterium tuberculosis (MTB), development of tuberculosis is influenced by environmental and host genetic factors, and clinical disease only occurs in less than 10% of the infected individuals. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of mycobacterium. This effect may be influenced by polymorphisms in the vitamin D receptor (VDR) gene. In the present study we investigated the impact of VDR gene variation in susceptibility to pulmonary tuberculosis.

  Materials and Methods: This study was a case-control analysis in an Iranian population. We evaluated four VDR gene polymorphisms [defined by the presence of restriction endonuclease sites for FokI (F/f), BsmI (B/b), TaqI (T/t), and ApaI (A/a)] in 96 patients with tuberculosis and 122 matched healthy controls. A modified polymerase chain reaction with sequence-specific primers (PCR-SSP) technique was used to identify these polymorphisms in VDR gene simultaneously.Chi square was used for data analysis.

  Results: Comparison of allele and genotype frequencies for the above VDR gene polymorphic sites revealed no significant difference between patient and control groups.

  Conclusion: This data may rule out the importance of VDR gene polymorphisms in susceptibility to tuberculosis among Iranian population.

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Type of Study: Research | Subject: Immunology

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