Volume 15, Issue 59 (summer 2008)                   RJMS 2008, 15(59): 165-172 | Back to browse issues page


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Mousavi, T, . Salek Moghaddam, A R, Falak, R, Sadeghipoor, A, Hejazi, M. Study of the Effects of CpG Oligonucleotides on IFN- γ and IgE Responses to Chenopodium Album Allergen in Murine Model of Asthma. RJMS. 2008; 15 (59) :165-172
URL: http://rjms.iums.ac.ir/article-1-1021-en.html

Associate Professor
Abstract:   (4717 Views)

Background & Aim:

and achieving safe prophylactic and therapeutic procedures is the main aim of the investigators. CpG

oligodeoxynucleotides (CpG ODN) which modulate the immune responses and change the cytokine patterns by several

mechanisms are among these procedures.

Worldwide increasing number of allergic disorders is one of the most important health challenges,

Material and Method:

Chenopodium album (CH.a), a common allergenic plant in Iran, in a murine model of asthma. We used CH. a pollen

extract with CpG to sensitize the mice and compared a number of immunologic parameters such as interferon gamma

(IFN-

lung culture supernatants. Histological studies were also conducted to identify inflammatory cells in lung airways. ANOVA

test was used to analyze the data.

In this experimental study we investigated the effects of CpG motif on immune responses toγ) and IgE levels between case and control groups. To do this, IFN-γ and IgE levels were measured in splenocyte and

Results:

by 80% and have a potent influence to augment both systemic and local levels of IFN-

The study showed although CpG ODN cannot reduce IgE levels to the normal range, they can lower IgE levelsγ as a Th1 activity marker (P<0.01)

Conclusion:

reducing lung inflammatory responses. Since CpG components have potency to shift immune activity from Th2 to Th1

responses, it seems that co-administration of CpG/antigen can modulate inflammatory responses to different allergenic

antigens.

The results of the study have consistency with other reports and confirm the benefits of CpG motifs in
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Type of Study: Research | Subject: Immunology

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